Evidence map›Paper›PMID 34958401›Full record

ArticleArchives of gynecology and obstetrics2022

The impact of Enhanced Recovery after Surgery (ERAS) pathways with regard to perioperative outcome in patients with ovarian cancer.

Susanne Reuter, Linn Woelber, Constantin C Trepte, Daniel Perez, Antonia Zapf, Sinan Cevirme, Volkmar Mueller, Barbara Schmalfeldt, Anna Jaeger

Open access · hybridAbstract read
In one paragraph

Article in Archives of gynecology and obstetrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Worldwide barriers of optimal surgical care provision in advanced ovarian cancer.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Review
  4. Review
  5. Observational
  6. Prospective evaluation of an enhanced recovery after surgery (ERAS) pathway in a Norwegian cohort of patients with suspected or advanced ovarian cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Susanne ReuterDepartment of Gynecology, Hamburg-Eppendorf University Medical Center, Martinistraße 52, 20246, Hamburg, Germany. s.reuter@uke.de.
Linn WoelberDepartment of Gynecology, Hamburg-Eppendorf University Medical Center, Martinistraße 52, 20246, Hamburg, Germany.
Constantin C TrepteDepartment of Anaesthesiology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany.
Daniel PerezDepartment of General, Visceral and Thoracic Surgery, Hamburg-Eppendorf University Medical Center, Hamburg, Germany.
Antonia ZapfInstitute of Medical Biometry and Epidemiology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Sinan CevirmeInstitute of Medical Biometry and Epidemiology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Volkmar MuellerDepartment of Gynecology, Hamburg-Eppendorf University Medical Center, Martinistraße 52, 20246, Hamburg, Germany.
Barbara SchmalfeldtDepartment of Gynecology, Hamburg-Eppendorf University Medical Center, Martinistraße 52, 20246, Hamburg, Germany.
Anna JaegerDepartment of Gynecology, Hamburg-Eppendorf University Medical Center, Martinistraße 52, 20246, Hamburg, Germany.
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMajor surgery for ovarian cancer is associated with significant morbidity. Recently, guidelines for perioperative care in gynecologic oncology with a structured "Enhanced Recovery after Surgery (ERAS)" program were presented. Our aim was to evaluate if implementation of ERAS reduces postoperative complications in patients undergoing extensive cytoreductive surgery for ovarian cancer.

methods134 patients with ovarian cancer (FIGO I-IV) were included. 47 patients were prospectively studied after implementation of a mandatory ERAS protocol (ERAS group) and compared to 87 patients that were treated before implementation (pre-ERAS group). Primary endpoints of this study were the effects of the ERAS protocol on postoperative complications and length of stay in hospital.

resultsPreoperative and surgical data were comparable in both groups. Only the POSSUM score was higher in the ERAS group (11.8% vs. 9.3%, p < 0.001), indicating a higher surgical risk in the ERAS group. Total number of postoperative complications (ERAS: 29.8% vs. pre-ERAS: 52.8%, p = 0.011), and length of hospital stay (ERAS: 11 (6-23) vs pre-ERAS: 13 (6-50) days; p < 0.001) differed significantly. A lower fraction of patients of the ERAS group (87.2%) needed postoperative admission to the ICU compared to the pre-ERAS group (97.7%), p = 0.022). Mortality within the ERAS group was 0% vs. 3.4% (p = 0.552) in the pre-ERAS group.

conclusionThe implementation of a mandatory ERAS protocol was associated with a lower rate of postoperative complications and a reduced length of stay in hospital. If ERAS has influence on long-term outcome needs to be further evaluated.

Indexed as

Enhanced Recovery After SurgeryOvarian NeoplasmsCarcinoma, Ovarian EpithelialFemaleHumansLength of StayPerioperative CarePostoperative ComplicationsEnhanced Recovery after Surgery (ERAS)Gynecologic oncologyLength of hospitalization/stay (LOS)Ovarian cancerPerioperative outcome

Identifiers

PMID34958401
PMCPMC9300507
OpenAlexW4200086265

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.