Evidence map›Paper›PMID 34958105›Full record

ArticleOncology reports2022

Anti‑VEGF antibody triggers the effect of anti‑PD‑L1 antibody in PD‑L1

Nobuyuki Ishikura, Masamichi Sugimoto, Keigo Yorozu, Mitsue Kurasawa, Osamu Kondoh

Open access · hybridAbstract read
In one paragraph

Article in Oncology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors.Journal of cancer research and clinical oncology · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Generation, secretion and degradation of cancer immunotherapy target PD-L1.Cellular and molecular life sciences : CMLS · 2022
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nobuyuki IshikuraProduct Research Department, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247‑8530, Japan.
Masamichi SugimotoProduct Research Department, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247‑8530, Japan.
Keigo YorozuProduct Research Department, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247‑8530, Japan.
Mitsue KurasawaProduct Research Department, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247‑8530, Japan.
Osamu KondohProduct Research Department, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247‑8530, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of programmed cell death‑ligand 1 (PD‑L1)/programmed cell death protein 1 (PD‑1) blockade therapy has been demonstrated but is limited in patients with PD‑L1

Indexed as

AnimalsCell Line, TumorDisease Models, AnimalDrug Therapy, CombinationFemaleMiceNeoplasmsProgrammed Cell Death 1 ReceptorVascular Endothelial Growth Factor APdcd1 protein, mouseProgrammed Cell Death 1 ReceptorVascular Endothelial Growth Factor Aanti‑programmed death‑ligand 1anti‑vascular endothelial growth factoratezolizumabbevacizumabC‑X‑C motif chemokine receptor 3 ligandsimmune desert

Identifiers

PMID34958105
PMCPMC8717122
OpenAlexW4200090702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.