ArticleThe Journal of infectious diseases2022
SARS-CoV-2 Infection During Pregnancy and Associated Perinatal Health Outcomes: A National US Cohort Study.
Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Observational
- The association between early pregnancy infection with SARS-CoV-2 and fetal birth defects: a prospective study.Scientific reports · 2026Article
- Severe acute respiratory syndrome coronavirus 2 and preterm birth, clinical implications-A register-based cohort study from Sweden.Pregnancy (Hoboken, N.J.) · 2025Article
- The association between pregnancy outcomes of frozen thawed embryo transfers and previous SARS-CoV-2 infections.Scientific reports · 2025Article
- Findings of Reduced Head Circumference with COVID-19 Infection in the Third Trimester: A Retrospective Cohort Study.Biomedicines · 2025Article
- The Effectiveness and Influence of COVID-19 Vaccination on Perinatal Individuals and Their Newborns: An Updated Meta-Analysis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Review
- COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study.The Lancet regional health. Europe · 2024Article
- Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts.PLoS pathogens · 2024Article
- Management of neonates with maternal prenatal coronavirus infection and influencing factors.Pediatric research · 2024Review
- Neonatal outcomes of maternal prenatal coronavirus infection.Pediatric research · 2024Review
- Effects of emerging SARS-CoV-2 on total and cause-specific maternal mortality: A natural experiment in Chile during the peak of the outbreak, 2020-2021.PLOS global public health · 2024Article
- Reduction in preterm birth among COVID-19-vaccinated pregnant individuals in the United States.American journal of obstetrics & gynecology MFM · 2023Article
- Mild/asymptomatic COVID-19 in unvaccinated pregnant mothers impairs neonatal immune responses.JCI insight · 2023Article
- Obstetrical and gynecologic implications of COVID-19: what have we learned over the first two years of the pandemic.Archives of gynecology and obstetrics · 2023Review
- Neonatal and maternal outcomes following SARS-CoV-2 infection and COVID-19 vaccination: a population-based matched cohort study.Nature communications · 2023Article
- Factors related to COVID-19 vaccination intention and uptake among childbearing women.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Temporal trends and determinants of COVID-19 vaccine series initiation after recent pregnancy.Human vaccines & immunotherapeutics · 2023Article
- The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis.Obstetrics & gynecology science · 2023Article
- Article
- Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
Abstract
backgroundAlthough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with increased risk of adverse perinatal health outcomes, few large-scale, community-based epidemiological studies have been conducted.
methodsWe conducted a national cohort study using deidentified administrative claims data for 78 283 pregnancies with estimated conception before 30 April 2020 and pregnancy end after 11 March 2020. We identified SARS-CoV-2 infections using diagnostic and laboratory testing data, and compared the risk of pregnancy outcomes using Cox proportional hazard models treating coronavirus disease 2019 (COVID-19) as a time-varying exposure and adjusting for baseline covariates.
resultsOf the pregnancies, 2655 (3.4%) had a documented SARS-CoV-2 infection. COVID-19 during pregnancy was not associated with risk of miscarriage, antepartum hemorrhage, or stillbirth, but was associated with 2-3 fold higher risk of induced abortion (adjusted hazard ratio [aHR], 2.60; 95% confidence interval [CI], 1.17-5.78), cesarean delivery (aHR, 1.99; 95% CI, 1.71-2.31), clinician-initiated preterm birth (aHR, 2.88; 95% CI, 1.93-4.30), spontaneous preterm birth (aHR, 1.79; 95% CI, 1.37-2.34), and fetal growth restriction (aHR, 2.04; 95% CI, 1.72-2.43).
conclusionsPrenatal SARS-CoV-2 infection was associated with increased risk of adverse pregnancy outcomes. Prevention could have fetal health benefits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.