ReviewJournal of back and musculoskeletal rehabilitation2022
Lumbar instability as an etiology of low back pain and its treatment by prolotherapy: A review.
Review in Journal of back and musculoskeletal rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07296653 (Efficacy of Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Prolotherapy in Acupoints in Chronic Non-specific Low Back Pain (cLBP) - A Randomized Control Trial
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Prolotherapy as a Regenerative Treatment in the Management of Chronic Low Back Pain: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Efficacy of neuromobilization in the treatment of low back pain: Systematic review and meta-analysis.PloS one · 2024Pooled it
- 4-Week Comparative Outcomes of Standard Physiotherapy, Balneotherapy Plus Physiotherapy and Dextrose Prolotherapy in Patients with Low Back Pain: A Non-Randomized Study.Medicina (Kaunas, Lithuania) · 2026Trial
- Trial
- Characterizing Initial Cervical Spine and Neurovascular Findings in 84 Consecutive Patients with Hypermobile Ehlers-Danlos Syndrome: A Retrospective Study.Journal of clinical medicine · 2026Article
- Laminectomy aloneWorld journal of orthopedics · 2026Review
- Functional and Neurological Outcomes After Spine Surgery and Neurorehabilitation for Chronic Discogenic Low Back Pain: A Prospective Observational Pre-Post Study.Healthcare (Basel, Switzerland) · 2026Article
- Robot-assisted pedicle screw placement in spinal surgery: an updated systematic umbrella review and meta-meta-analysis of comparisons against freehand and navigation-guided techniques.EFORT open reviews · 2026Article
- Radiographic and clinical predictors of surgical outcomes following endoscopic decompression for radiculopathy in adult degenerative scoliosis: A multi-center retrospective study.Brain & spine · 2026Article
- Toward function-oriented, neuroscience-based spine care in older adults: a structured narrative review and translational synthesis.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- The evolving landscape of minimally invasive procedures in musculoskeletal diseases-Part II.Frontiers in medicine · 2026Review
- Comparative analysis of single vs. double cage insertion in unilateral biportal endoscopic lumbar interbody fusion: clinical and radiological outcomes.Frontiers in surgery · 2026Article
- Biomechanical compensatory chain and residual compensation potential in aging spinal deformity: a narrative review and multimodal assessment framework.Frontiers in medicine · 2026Review
- Clinical outcomes of unilateral biportal endoscopic discectomy vs. microdiscectomy in lumbar disc herniation.Frontiers in medicine · 2026Article
- The role of spinal and hip mobility in disability among patients with chronic low back pain.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Article
- Diaphragm excursion and thickness in patients with chronic low back pain with and without lumbar instability.Scientific reports · 2025Article
- The gender difference in the effects of air pollution on the risk of spinal osteoarthritis in Chinese middle-aged and older adults: a prospective cohort study in China.Frontiers in public health · 2025Article
- Therapeutic efficacy of endoscopic lumbar interbody fusion in patients with lumbar instability and analysis of prognostic factors.American journal of translational research · 2025Article
- Risk factors and interaction effects in recurrent low back pain.American journal of translational research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow back pain is a significant spinal disorder that affects much of the population at some point during their lives.
objectiveWhile proper diagnosis is key, diagnosing the underlying cause of low back pain may often be unclear.
methodIn this review article, we discuss lumbar instability as an etiology of low back pain and its treatment by prolotherapy.
resultsSpinal ligaments may be an underlying culprit in the development of lumbar instability with resultant low back pain and associated disorders.
conclusionIn these cases, adequate treatment consisting of non-biologic prolotherapy or cellular prolotherapy, including platelet rich plasma (PRP), can be beneficial in restoring spinal stability and resolving chronic low back pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.