ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022
Computational validity: using computation to translate behaviours across species.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Reward pursuit during a translational reward task correlates with anhedonia reductions following rTMS in patients with major depressive disorder.Translational psychiatry · 2026Article
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- Cognitive Strategy Accounts for Failure on a Relational Memory Task in Non-Human Primates.Hippocampus · 2026Article
- Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Beyond reward learning deficits: Exploration-exploitation instability reveals computational heterogeneity in value-based decision making in early psychosis.medRxiv : the preprint server for health sciences · 2025Article
- Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025Article
- Neuroeconomically dissociable forms of mental accounting are altered in a mouse model of diabetes.Communications biology · 2025Article
- Understanding How Acute Alcohol Impacts Neural Encoding in the Rodent Brain.Current topics in behavioral neurosciences · 2025Review
- A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies.Biological psychiatry · 2024Article
- Oxytocin and its links through scientific lineage.Comprehensive psychoneuroendocrinology · 2024Article
- Current and Future Approaches to Pediatric Anxiety Disorder Treatment.The American journal of psychiatry · 2024Review
- From palm to practice: prescription digital therapeutics for mental and brain health at the National Institutes of Health.Frontiers in psychiatry · 2024Article
- Article
- A Multi-task Platform for Profiling Cognitive and Motivational Constructs in Humans and Nonhuman Primates.bioRxiv : the preprint server for biology · 2023Article
- Switching to online: Testing the validity of supervised remote testing for online reinforcement learning experiments.Behavior research methods · 2023Article
- Prolonged Physiological Stress Is Associated With a Lower Rate of Exploratory Learning That Is Compounded by Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- From Computation to Clinic.Biological psychiatry global open science · 2023Review
- Pathways to the persistence of drug use despite its adverse consequences.Molecular psychiatry · 2023Review
Corrections and comments
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Authors and funding
16 authors.
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Abstract
We propose a new conceptual framework (computational validity) for translation across species and populations based on the computational similarity between the information processing underlying parallel tasks. Translating between species depends not on the superficial similarity of the tasks presented, but rather on the computational similarity of the strategies and mechanisms that underlie those behaviours. Computational validity goes beyond construct validity by directly addressing questions of information processing. Computational validity interacts with circuit validity as computation depends on circuits, but similar computations could be accomplished by different circuits. Because different individuals may use different computations to accomplish a given task, computational validity suggests that behaviour should be understood through the subject's point of view; thus, behaviour should be characterized on an individual level rather than a task level. Tasks can constrain the computational algorithms available to a subject and the observed subtleties of that behaviour can provide information about the computations used by each individual. Computational validity has especially high relevance for the study of psychiatric disorders, given the new views of psychiatry as identifying and mediating information processing dysfunctions that may show high inter-individual variability, as well as for animal models investigating aspects of human psychiatric disorders. This article is part of the theme issue 'Systems neuroscience through the lens of evolutionary theory'.
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