ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022
The whole prefrontal cortex is premotor cortex.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed.
- Learning to infer transitively on a mental line in premotor cortex.Science advances · 2026Article
- Learning and Using Different Task Rule Updating Strategies Require Extensive Practice.Cognitive science · 2026Article
- Advancing Stroke Recovery Through Operant Conditioning of Corticomuscular Coherence.Restorative neurology and neuroscience · 2026Review
- Dynamics of oscillatory power support the integration of perceptual and mnemonic information within the premotor cortex.Nature communications · 2026Article
- Evaluation of Brain Microstructural Alterations in Preschool Autism Spectrum Disorder: A Voxel-Wise Multimodal MRI Study.Journal of magnetic resonance imaging : JMRI · 2026Article
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- Rethinking the centrality of brain areas in understanding functional organization.Nature neuroscience · 2026Review
- Prefrontal Hierarchical Control of Corticomuscular Coherence in Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Superstitious conditioning shapes the illusory experience of free will under causal determinism.Frontiers in human neuroscience · 2026Article
- Differential Impacts of Fronto-Cerebellar tACS and tVNS on Motor Learning: Evidence for Sex-Related Neural Modulation.Neural plasticity · 2026Article
- From fingers to brain: virtual reality-based test capturing fine hand movements predicts cognitive function in older adults.Innovation in aging · 2025Article
- Global Cognition and Inhibition as Predictors of Dynamic Balance in Aging Populations: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Neural evidence that humans reuse strategies to solve new tasks.PLoS biology · 2025Article
- Article
- Brain-hemispheric differences in the premotor area for motor planning: An approach based on corticomuscular connectivity during motor decision-making.NeuroImage · 2025Article
- Lifespan oscillatory dynamics in lexical production: A population-based MEG resting-state analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The Cost of Regulating Effort: Reward and Difficulty Cues With Longer Prediction Horizons Have a Stronger Impact on Performance.Journal of cognition · 2025Article
- The brain on expert medical performance: a systematic review and activation likelihood estimation functional magentic resonance imaging meta-analysis.Psychoradiology · 2025Review
- Volumetric Analysis of Motor Cortex and Basal Ganglia in Pediatric Celiac Disease Patients Using volBrain: Implications for Neurological Dysfunction-Preliminary Results.Diagnostics (Basel, Switzerland) · 2024Article
- Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson's disease.Brain : a journal of neurology · 2024Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We propose that the entirety of the prefrontal cortex (PFC) can be seen as fundamentally premotor in nature. By this, we mean that the PFC consists of an action abstraction hierarchy whose core function is the potentiation and depotentiation of possible action plans at different levels of granularity. We argue that the apex of the hierarchy should revolve around the process of goal-selection, which we posit is inherently a form of optimization over action abstraction. Anatomical and functional evidence supports the idea that this hierarchy originates on the orbital surface of the brain and extends dorsally to motor cortex. Accordingly, our viewpoint positions the orbitofrontal cortex in a key role in the optimization of goal-selection policies, and suggests that its other proposed roles are aspects of this more general function. Our proposed perspective will reframe outstanding questions, open up new areas of inquiry and align theories of prefrontal function with evolutionary principles. This article is part of the theme issue 'Systems neuroscience through the lens of evolutionary theory'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.