Evidence map›Paper›PMID 34957534›Full record

ArticleJapanese journal of ophthalmology2022

Dry age-related macular degeneration in the Japanese population.

Akitaka Tsujikawa, Kanji Takahashi, Ryo Obata, Tomohiro Iida, Yasuo Yanagi, Hideki Koizumi, Hidetoshi Yamashita, Fumio Shiraga, Taiji Sakamoto

Abstract read
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In one paragraph

Article in Japanese journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
  3. Geographic atrophy in Asia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 1 country.

Akitaka TsujikawaDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kanji TakahashiDepartment of Ophthalmology, Kansai Medical University, Hirakata, Osaka, 573-1191, Japan. takahask@takii.kmu.ac.jp.
Ryo ObataDepartment of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tomohiro IidaDepartment of Ophthalmology, Tokyo Women's Medical University, Tokyo, Japan.
Yasuo YanagiDepartment of Ophthalmology and Micro-Technology, Yokohama City University, Yokohama, Japan.
Hideki KoizumiDepartment of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Nakagami-gun, Okinawa, Japan.
Hidetoshi YamashitaDepartment of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, Yamagata, Japan.
Fumio ShiragaDepartment of Ophthalmology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Taiji SakamotoDepartment of Ophthalmology, Kagoshima University, Kagoshima, Japan.
Kagoshima University · JPKansai Medical University · JPKyoto University · JPOkayama University · JPThe University of Tokyo · JPTokyo Women's Medical University · JPUniversity of the Ryukyus · JPYamagata University · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo elucidate the clinical characteristics of eyes with dry age-related macular degeneration (AMD) in Japan. STUDY

designRetrospective.

methodsWe performed a nationwide survey of dry AMD. A questionnaire on dry AMD was sent to 3,801 major hospitals and eye clinics nationwide. Whenever both eyes met the diagnostic criteria, only the eye with more advanced geographic atrophy was included.

resultsIn the current survey, 81 patients (81 eyes) with dry AMD were included. Of the 81 patients, 56 (69.1%) were men, and the mean age of the patients was 76.6 ± 8.4 (range, 54-94) years. Twenty-four patients (29.6%) had a history of smoking. The decimal best corrected-visual acuity (BCVA) was equal to or better than 0.7 in 25 eyes (30.9%), but worse than 0.1 in 17 eyes (21.0%). The mean BCVA was 0.62 ± 0.59 in logarithm of the minimum angle of resolution. Lesion size (the greatest linear dimension of the largest geographic atrophy) was ≥ 2 disc diameter in 33 eyes (40.7%) and < 1 disc diameter in 21 eyes (25.9%). Soft drusen was observed in 27 eyes (33.3%), and reticular pseudodrusen was observed in 31 eyes (38.3%). Of the 81 patients, the other eye was diagnosed as dry AMD in 26 eyes (32.1%), neovascular AMD in 16 eyes (19.8%), and intermediate AMD in 18 eyes (22.2%).

conclusionDry AMD in the Japanese population has characteristics of male predominance, older age, high prevalence of reticular pseudodrusen, and high bilaterality.

Indexed as

Geographic AtrophyRetinal DrusenWet Macular DegenerationAgedAged, 80 and overAngiogenesis InhibitorsHumansJapanMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceVascular Endothelial Growth Factor AVisual AcuityAngiogenesis InhibitorsVascular Endothelial Growth Factor ADrusenDry age-related macular degenerationGeographic atrophyReticular pseudodrusenSmoking

Identifiers

PMID34957534
OpenAlexW4200044491

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.