Evidence map›Paper›PMID 34957532›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Reductions in sleep quality and circadian activity rhythmicity predict longitudinal changes in objective and subjective cognitive functioning in women treated for breast cancer.

Sonia Ancoli-Israel, Lianqi Liu, Loki Natarajan, Michelle Rissling, Ariel B Neikrug, Shawn D Youngstedt, Paul J Mills, Georgia R Sadler, Joel E Dimsdale, Barbara A Parker and 1 more

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  9. Being in the right place at the right time.Sleep advances : a journal of the Sleep Research Society · 2025
    Article
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  11. Age Is Associated With Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility, and Aging (SOMMA).The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sonia Ancoli-IsraelDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0737, USA. sancoliisrael@health.ucsd.edu.ORCID http://orcid.org/0000-0002-0662-8865
Lianqi LiuDepartment of Medicine, University of California, San Diego, San Diego, CA, USA.
Loki NatarajanUniversity of California, San Diego Moores Cancer Center, San Diego, CA, USA.
Michelle RisslingDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0737, USA.
Ariel B NeikrugDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
Shawn D YoungstedtEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA.
Paul J MillsFamily Medicine and Public Health, University of California, San Diego, San Diego, CA, USA.
Georgia R SadlerUniversity of California, San Diego Moores Cancer Center, San Diego, CA, USA.
Joel E DimsdaleDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0737, USA.
Barbara A ParkerUniversity of California, San Diego Moores Cancer Center, San Diego, CA, USA.
Barton W PalmerDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0737, USA.

Funding

SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
Contributions of sleep/rhythms/fatigue to chemobrainR01CA112035 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANCOLI-ISRAEL, SONIA · 2005 to 2009
$1.8M
NCI NIH HHS CA112035NCI NIH HHS R01 CA112035NCRR NIH HHS UL1 RR031980NIH HHS UL1RR031980U.S. Department of Veterans Affairs CESAMH
6 · The paper itself

Abstract

purposeTo examine long-term cognitive effects of chemotherapy and identify predictors among women with breast cancer (WBC). PATIENTS AND

methodsSixty-nine WBC scheduled to receive chemotherapy, and 64 matched-controls with no cancer, participated. Objective and subjective cognition, total sleep time, nap time, circadian activity rhythms (CAR), sleep quality, fatigue, and depression were measured pre-chemotherapy (Baseline), end of cycle 4 (Cycle-4), and one-year post-chemotherapy (1-Year).

resultsWBC showed no change in objective cognitive measures from Baseline to Cycle-4 but significantly improved from both time points to 1-Year. Matched-controls showed an increase in test performance at all time points. WBC had significantly higher self-reported cognitive dysfunction at Cycle-4 and 1-Year compared to baseline and compared to matched-controls. Worse neuropsychological functioning was predicted by less robust CARs (i.e., inconsistent 24 h pattern), worse sleep quality, longer naps, and worse cognitive complaints. Worse subjective cognition was predicted by lower sleep quality and higher fatigue and depressed mood.

conclusionObjective testing showed increases in performance scores from pre- and post-chemotherapy to one year later in WBC, but matched-controls showed an increase in test performance from baseline to Cycle-4 and from Cycle-4 to 1-Year, likely due to a practice effect. The fact that WBC showed no practice effects may reflect a form of learning deficit. Compared with the matched-controls, WBC reported significant worsened cognitive function. In WBC, worse objective and subjective cognitive functioning were predicted by worse sleep and sleep-related behaviors (naps and CAR). Interventions that target sleep, circadian rhythms, and fatigue may benefit cognitive function in WBC.

Indexed as

Breast NeoplasmsCircadian RhythmCognitionFatigueFemaleHumansQuality of LifeSleepSleep QualityBreast cancerChemotherapyCircadian activity rhythmsCognitive functionDepressionFatigueSleep quality

Identifiers

PMID34957532
PMCPMC8857013

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.