Evidence map›Paper›PMID 34957471›Full record

ArticleCancer research communications2021

Sex- and mutation-specific p53 gain-of-function activity in gliomagenesis.

Nathan C Rockwell, Wei Yang, Nicole M Warrington, Max V Staller, Malachi Griffith, Obi L Griffith, Christina A Gurnett, Barak A Cohen, Dustin Baldridge, Joshua B Rubin

Open access · goldAbstract read
In one paragraph

Article in Cancer research communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nathan C RockwellDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wei YangDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nicole M WarringtonDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Max V StallerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Malachi GriffithDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Obi L GriffithDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Christina A GurnettDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Barak A CohenDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dustin BaldridgeDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joshua B RubinDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · USJames S. McDonnell Foundation · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
MOLECULAR BASIS FOR THE IMPACT OF SEX ON BRAIN TUMORIGENESISR01CA174737 · NCI · WASHINGTON UNIVERSITY · PI RUBIN, JOSHUA B · 2014 to 2024
$3.5M
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA174737
6 · The paper itself

Abstract

In cancer, missense mutations in the DNA-binding domain of

Indexed as

GlioblastomaTumor Suppressor Protein p53AnimalsDNAFemaleGain of Function MutationMaleMiceMutationNeoplasm Recurrence, LocalDNATumor Suppressor Protein p53gain-of-functionglioblastomap53sex differencestranscription

Identifiers

PMID34957471
PMCPMC8694557
OpenAlexW4200011027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.