ArticleLancet regional health. Americas2021
Impact of common cardio-metabolic risk factors on fatal and non-fatal cardiovascular disease in Latin America and the Caribbean: an individual-level pooled analysis of 31 cohort studies.
Article in Lancet regional health. Americas, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Implementation of stroke prevention: a review of challenges and opportunities in the Americas.Lancet regional health. Americas · 2026Review
- Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Women's Cardiovascular Health: A Current Challenge.Arquivos brasileiros de cardiologia · 2026Article
- Economic Evaluation of the HEARTS Standardized Hypertension Treatment Program With Fixed-Dose Combination Pills in Chile Primary Care Clinics.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2025Article
- Complex interaction of waist circumference, cardiometabolic markers, and sex on elderly mortality: a cohort study of 0.4 million UK adults.npj metabolic health and disease · 2025Article
- Article
- Epidemiology of cardiometabolic health in Latin America and strategies to address disparities.Nature reviews. Cardiology · 2024Review
- Association between maternal cardiometabolic markers and fetal growth in non-complicated pregnancies: a secondary analysis of the PRINCESA cohort.Scientific reports · 2024Article
- Reproductive factors and cardiometabolic disease among middle-aged and older women: a nationwide study from CHARLS.Frontiers in cardiovascular medicine · 2024Article
- Data for population-based health analytics: the Cohorts Consortium of Latin America and the Caribbean.Revista panamericana de salud publica = Pan American journal of public health · 2024Article
- Cardiovascular disease and all-cause mortality associated with individual and combined cardiometabolic risk factors.BMC public health · 2023Article
- Prevalence of hypertriglyceridemia among Royal Thai Army personnel and its related cardiometabolic risk factors, from 2017 to 2021.BMC public health · 2022Article
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Authors and funding
1 author.
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Abstract
Background: Estimates of the burden of cardio-metabolic risk factors in Latin America and the Caribbean (LAC) rely on relative risks (RRs) from non-LAC countries. Whether these RRs apply to LAC remains unknown. Methods: We pooled LAC cohorts. We estimated RRs per unit of exposure to body mass index (BMI), systolic blood pressure (SBP), fasting plasma glucose (FPG), total cholesterol (TC) and non-HDL cholesterol on fatal (31 cohorts, n=168,287) and non-fatal (13 cohorts, n=27,554) cardiovascular diseases, adjusting for regression dilution bias. We used these RRs and national data on mean risk factor levels to estimate the number of cardiovascular deaths attributable to non-optimal levels of each risk factor. Results: Our RRs for SBP, FPG and TC were like those observed in cohorts conducted in high-income countries; however, for BMI, our RRs were consistently smaller in people below 75 years of age. Across risk factors, we observed smaller RRs among older ages. Non-optimal SBP was responsible for the largest number of attributable cardiovascular deaths ranging from 38 per 100,000 women and 54 men in Peru, to 261 (Dominica, women) and 282 (Guyana, men). For non-HDL cholesterol, the lowest attributable rate was for women in Peru (21) and men in Guatemala (25), and the largest in men (158) and women (142) from Guyana. Interpretation: RRs for BMI from studies conducted in high-income countries may overestimate disease burden metrics in LAC; conversely, RRs for SBP, FPG and TC from LAC cohorts are similar to those estimated from cohorts in high-income countries. Funding: Wellcome Trust (214185/Z/18/Z).
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