Evidence map›Paper›PMID 34957380›Full record

ArticleiScience2022

Persistence of functional memory B cells recognizing SARS-CoV-2 variants despite loss of specific IgG.

Stephan Winklmeier, Katharina Eisenhut, Damla Taskin, Heike Rübsamen, Ramona Gerhards, Celine Schneider, Paul R Wratil, Marcel Stern, Peter Eichhorn, Oliver T Keppler and 4 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 29 citations in OpenAlex.

  1. Extending ImmunoSpotVaccines · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Stephan WinklmeierInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Katharina EisenhutInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Damla TaskinInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Heike RübsamenInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Ramona GerhardsInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Celine SchneiderInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Paul R WratilMax von Pettenkofer Institute & GeneCenter, Virology, LMU Munich, 80336 Munich, Germany.
Marcel SternMax von Pettenkofer Institute & GeneCenter, Virology, LMU Munich, 80336 Munich, Germany.
Peter EichhornInstitute of Laboratory Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Oliver T KepplerMax von Pettenkofer Institute & GeneCenter, Virology, LMU Munich, 80336 Munich, Germany.
Matthias KleinDepartment of Neurology, University Hospital, LMU Munich, 81377 Munich, Germany.
Simone MaderInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Tania KümpfelInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
Edgar MeinlInstitute of Clinical Neuroimmunology, University Hospital, LMU Munich, 81377 Munich, Germany.
LMU Klinikum · DELudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although some COVID-19 patients maintain SARS-CoV-2-specific serum immunoglobulin G (IgG) for more than 6 months postinfection, others eventually lose IgG levels. We assessed the persistence of SARS-CoV-2-specific B cells in 17 patients, 5 of whom had lost specific IgGs after 5-8 months. Differentiation of blood-derived B cells

Indexed as

Biological sciencesImmune responseImmunology

Identifiers

PMID34957380
PMCPMC8686444
OpenAlexW4225523515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.