Evidence map›Paper›PMID 34957277›Full record

ReviewFrontiers in veterinary science2021

Proposed Diagnostic Criteria and Classification of Canine Mast Cell Neoplasms: A Consensus Proposal.

Michael Willmann, Vilma Yuzbasiyan-Gurkan, Laura Marconato, Mauro Dacasto, Emir Hadzijusufovic, Olivier Hermine, Irina Sadovnik, Susanne Gamperl, Mathias Schneeweiss-Gleixner, Karoline V Gleixner and 15 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in veterinary science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cutaneous mast cell tumors in dogs: Association with gonadectomy.Brazilian journal of veterinary medicine · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Mutational Landscape ofVeterinary sciences · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Anal sac mast cell tumor in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 5 countries.

Michael WillmannDepartment/Hospital for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria.
Vilma Yuzbasiyan-GurkanComparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI, United States.
Laura MarconatoDepartment of Veterinary Medical Science, University of Bologna, Ozzano dell'Emilia, Italy.
Mauro DacastoDepartment of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.
Emir HadzijusufovicDepartment/Hospital for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria.
Olivier HermineDepartment of Hematology, Imagine Institute Université de Paris, INSERM U1163, CEREMAST, Necker Hospital, Paris, France.
Irina SadovnikLudwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Susanne GamperlLudwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Mathias Schneeweiss-GleixnerLudwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Karoline V GleixnerDivision of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Thomas BöhmDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Barbara PeterLudwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Gregor EisenwortLudwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Richard MorigglInstitute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria.
Zhixiong LiDepartment of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hanover Medical School, Hanover, Germany.
Mohamad JawharDepartment of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Karl SotlarInstitute of Pathology, Paracelsus Medical University of Salzburg, Salzburg, Austria.
Erika Jensen-JarolimCenter of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Veronika SexlInstitute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria.
Hans-Peter HornyInstitute of Pathology, Paracelsus Medical University of Salzburg, Salzburg, Austria.
Stephen J GalliDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, United States.
Michel ArockLaboratory of Hematology, Pitié-Salpêtrière Hospital, Paris, France.
David M VailDepartment of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Matti KiupelPathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, United States.
Peter ValentLudwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATUniversity of Veterinary Medicine Vienna · ATMichigan State University · USHeidelberg University · DEInserm · FRLudwig-Maximilians-Universität München · DEMedizinische Hochschule Hannover · DESorbonne Université · FRStanford University · USUniversity of Bologna · ITUniversity of Padua · ITUniversity of Salzburg · ATUniversity of Wisconsin Carbone Cancer Center · US

Funding

Austrian Science Fund FWF P 32470
6 · The paper itself

Abstract

Mast cell neoplasms are one of the most frequently diagnosed malignancies in dogs. The clinical picture, course, and prognosis vary substantially among patients, depending on the anatomic site, grade and stage of the disease. The most frequently involved organ is the skin, followed by hematopoietic organs (lymph nodes, spleen, liver, and bone marrow) and mucosal sites of the oral cavity and the gastrointestinal tract. In cutaneous mast cell tumors, several grading and staging systems have been introduced. However, no comprehensive classification and no widely accepted diagnostic criteria have been proposed to date. To address these open issues and points we organized a Working Conference on canine mast cell neoplasms in Vienna in 2019. The outcomes of this meeting are summarized in this article. The proposed classification includes cutaneous mast cell tumors and their sub-variants defined by grading- and staging results, mucosal mast cell tumors, extracutaneous/extramucosal mast cell tumors without skin involvement, and mast cell leukemia (MCL). For each of these entities, diagnostic criteria are proposed. Moreover, we have refined grading and staging criteria for mast cell neoplasms in dogs based on consensus discussion. The criteria and classification proposed in this article should greatly facilitate diagnostic evaluation and prognostication in dogs with mast cell neoplasms and should thereby support management of these patients in daily practice and the conduct of clinical trials.

Indexed as

canine mast cell neoplasmclassificationgradingKIT mutationsstagingtargeted therapytreatment algorithms

Identifiers

PMID34957277
PMCPMC8702826
OpenAlexW4200297748

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.