Evidence map›Paper›PMID 34957104›Full record

ArticleFrontiers in cell and developmental biology2021

Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma.

Wenhao Xu, Wenkai Zhu, Xi Tian, Wangrui Liu, Yuanyuan Wu, Aihetaimujiang Anwaier, Jiaqi Su, Shiyin Wei, Yuanyuan Qu, Hailiang Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Beyond mBiomedicines · 2026
    Review
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  5. Role of main RNA modifications in cancer: NSignal transduction and targeted therapy · 2022
    Review
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Wenhao XuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Wenkai ZhuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Xi TianDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Wangrui LiuDepartment of Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Yuanyuan WuDepartment of Gastroenterology, Naval Medical Center of PLA, Naval Military Medical University, Shanghai, China.
Aihetaimujiang AnwaierDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Jiaqi SuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Shiyin WeiDepartment of Neurosurgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Yuanyuan QuDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Hailiang ZhangDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Dingwei YeDepartment of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Fudan University Shanghai Cancer Center · CNShanghai Medical College of Fudan University · CNAffiliated Hospital of Youjiang Medical University for Nationalities · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor microenvironment (TME) affects the biologic malignancy of clear cell renal cell carcinoma (ccRCC). The influence of the 5-methylcytosine (m

Indexed as

5-methylcytosineclear cell renal cell carcinomaimmune checkpoint therapiesmachine learning algorithmprognosisrenal cell carcinoma (RCC) clear cell renal cell carcinoma (CCRCC)tumor microenvironment

Identifiers

PMID34957104
PMCPMC8694268
OpenAlexW4200565253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.