Evidence map›Paper›PMID 34957080›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Studying the Mechanobiology of Aortic Endothelial Cells Under Cyclic Stretch Using a Modular 3D Printed System.

Sergio Aguilera Suarez, Nadia Chandra Sekar, Ngan Nguyen, Austin Lai, Peter Thurgood, Ying Zhou, Scott Needham, Elena Pirogova, Khashayar Khoshmanesh, Sara Baratchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sergio Aguilera SuarezSchool of Engineering, RMIT University, Melbourne, VIC, Australia.
Nadia Chandra SekarSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
Ngan NguyenSchool of Engineering, RMIT University, Melbourne, VIC, Australia.
Austin LaiSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
Peter ThurgoodSchool of Engineering, RMIT University, Melbourne, VIC, Australia.
Ying ZhouSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
Scott NeedhamLeading Technology Group, Melbourne, VIC, Australia.
Elena PirogovaSchool of Engineering, RMIT University, Melbourne, VIC, Australia.
Khashayar KhoshmaneshSchool of Engineering, RMIT University, Melbourne, VIC, Australia.
Sara BaratchiSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
RMIT University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we describe a motorized cam-driven system for the cyclic stretch of aortic endothelial cells. Our modular design allows for generating customized spatiotemporal stretch profiles by varying the profile and size of 3D printed cam and follower elements. The system is controllable, compact, inexpensive, and amenable for parallelization and long-term experiments. Experiments using human aortic endothelial cells show significant changes in the cytoskeletal structure and morphology of cells following exposure to 5 and 10% cyclic stretch over 9 and 16 h. The system provides upportunities for exploring the complex molecular and cellular processes governing the response of mechanosensitive cells under cyclic stretch.

Indexed as

3D printingbiomechanicscyclic stretchendothelialmechanobiologymechanotransduction

Identifiers

PMID34957080
PMCPMC8698250
OpenAlexW4200520215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.