Evidence map›Paper›PMID 34956848›Full record

ArticlePublic health action2021

The impact of changing the diagnostic algorithm for TB in Manicaland, Zimbabwe.

K Zvinoera, I D Olaru, P Khan, J Mutsvangwa, C M Denkinger, V Kampira, D Coutinho, H Mutunzi, M Pepukai, E Chikaka and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Public health action, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

K ZvinoeraMinistry of Health and Child Care, Mutare Provincial Hospital, Mutare, Zimbabwe.
I D OlaruClinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.
P KhanClinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.
J MutsvangwaBiomedical Research and Training Institute, Harare, Zimbabwe.
C M DenkingerDivision of Tropical Medicine, Centre for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
V KampiraMinistry of Health and Child Care, Mutare Provincial Hospital, Mutare, Zimbabwe.
D CoutinhoMinistry of Health and Child Care, Mutare Provincial Hospital, Mutare, Zimbabwe.
H MutunziAIDS and TB Department, Ministry of Health and Child Care, Harare, Zimbabwe.
M PepukaiBiomedical Research and Training Institute, Harare, Zimbabwe.
E ChikakaDepartment of Health Sciences, College of Health and Natural Sciences, Africa University, Old Mutare, Zimbabwe.
S ZinyoweraNational Microbiology Reference Laboratory, Ministry of Health and Child Care, Harare, Zimbabwe.
S MharakurwaDepartment of Health Sciences, College of Health and Natural Sciences, Africa University, Old Mutare, Zimbabwe.
K KranzerClinical Research Department, London School of Hygiene & Tropical Medicine, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

settingGovernmental health facilities performing TB diagnostics in Manicaland, Zimbabwe.

objectiveTo investigate the effect of making Xpert® MTB/RIF the primary TB diagnostic for all patients presenting with presumptive TB on 1) the number of samples investigated for TB, 2) the proportion testing TB-positive, and 3) the proportion of unsuccessful results over time.

designThis retrospective study used data from GeneX-pert downloads, laboratory registers and quality assurance reports between 1 January 2017 and 31 December 2018.

resultsThe total number of Xpert tests performed in Manicaland increased from 3,967 in the first quarter of 2017 to 7,011 in the last quarter of 2018.

conclusionRoll out of more sensitive TB diagnostics does not necessarily result in an increase of microbiologically confirmed TB diagnosis. While the number of samples tested using Xpert increased, the proportion of TB-positive tests decreased. GeneXpert soft- and hardware infrastructure needs to be strengthened to reduce the rate of unsuccessful assays and therefore, costs and staff time.

Indexed as

diagnosticstuberculosisXpert MTB/RifZimbabwe

Identifiers

PMID34956848
PMCPMC8680185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.