Evidence map›Paper›PMID 34956833›Full record

ArticlePhotoacoustics2021

High-speed functional photoacoustic microscopy using a water-immersible two-axis torsion-bending scanner.

Maomao Chen, Xiaoyu Duan, Bangxin Lan, Tri Vu, Xiaoyi Zhu, Qiangzhou Rong, Wei Yang, Ulrike Hoffmann, Jun Zou, Junjie Yao

Open access · goldAbstract read
In one paragraph

Article in Photoacoustics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Current trends in the characterization and monitoring of vascular response to cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
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  9. Review
  10. Photoacoustic imaging plus X: a review.Journal of biomedical optics · 2024
    Review
  11. Article
  12. Journal of biomedical optics · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Photoacoustics · 2023
    Article
  18. Efficient label-freePhotoacoustics · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Maomao ChenDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Xiaoyu DuanDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
Bangxin LanDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Tri VuDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Xiaoyi ZhuDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Qiangzhou RongDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Wei YangDepartment of Anaesthesiology, Duke University School of Medicine, Durham, NC 27708, USA.
Ulrike HoffmannDepartment of Anaesthesiology, Duke University School of Medicine, Durham, NC 27708, USA.
Jun ZouDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843, USA.
Junjie YaoDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Duke University · USTexas A&M University · US

Funding

High-resolution High-speed Photoacoustic and Ultrasound Imaging of SmallVessel Functions in Ischemic StrokeR01NS111039 · NINDS · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2023
$2.7M
Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving AnimalsRF1NS115581 · NINDS · DUKE UNIVERSITY · PI VERKHUSHA, VLADISLAV, YAO, JUNJIE · 2020 to 2020
$2.0M
High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
Transcranial Photoacoustic Imaging Using a Virtual ArrayR21EB027981 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI JING, YUN · 2020 to 2020
$455k
Photoacoustic-imaging-guided intravascular sonothrombolysisR21EB027304 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI JIANG, XIAONING, YAO, JUNJIE · 2019 to 2020
$411k
NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R21 EB027304NIBIB NIH HHS R21 EB027981NINDS NIH HHS R01 NS111039NINDS NIH HHS RF1 NS115581
6 · The paper itself

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) can provide functional, anatomical, and molecular images at micrometer level resolution with an imaging depth of less than 1 mm in tissue. However, the imaging speed of traditional OR-PAM is often low due to the point-by-point mechanical scanning and cannot capture time-sensitive dynamic information. In this work, we demonstrate a recent effort in improving the imaging speed of OR-PAM, using a newly developed water-immersible two-axis scanner. Driven by water-compatible electromagnetic actuation force, the new scanning mirror employs a novel torsion-bending mechanism to achieve fast 2D scanning. The torsion scanning along the fast-axis works in the resonant model, and the bending scanning along the slow-axis operate at the quasi-static mode. The scanning speed and scanning range along the two axes can be independently adjusted. Steered by the two-axis torsion-bending scanning mirror immersed in water, the focused excitation light and the generated acoustic wave can be confocally aligned over the entire imaging area. Thus, a high imaging speed can be achieved without sacrificing the detection sensitivity. Equipped with the torsion-bending scanner, the high-speed OR-PAM system has achieved a cross-sectional frame rate of 400 Hz, and a volumetric imaging speed of 1 Hz over a field of view of 1.5 × 2.5 mm

Indexed as

EpinephrineFunctional imagingHigh-speed imagingHypoxiaPhotoacoustic microscopyTorsion-bending scanningTwo-axis scanning mirrorVessel constrictionWater immersible

Identifiers

PMID34956833
PMCPMC8674646
OpenAlexW3205359770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.