Evidence map›Paper›PMID 34956624›Full record

ArticleToxicology research2021

A new cytometry-based method reveals an accumulation of Nrf2 in dendritic cells exposed to two respiratory sensitizers.

Adrien Audry, Julianne Mathiot, Samuel Muller, Amélie Coiscaud, Isabelle Langonné, Fabrice Battais, Brigitte Leininger, Isabelle Sponne

Open access · bronzeAbstract read
In one paragraph

Article in Toxicology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Adrien AudryDepartment of Toxicology and Biometrology, National Institute for Research and Safety (INRS), rue du Morvan - 54500 Vandœuvre-lès-Nancy, France.ORCID https://orcid.org/0000-0002-7343-4059
Julianne MathiotDepartment of Toxicology and Biometrology, National Institute for Research and Safety (INRS), rue du Morvan - 54500 Vandœuvre-lès-Nancy, France.
Samuel MullerDepartment of Toxicology and Biometrology, National Institute for Research and Safety (INRS), rue du Morvan - 54500 Vandœuvre-lès-Nancy, France.
Amélie CoiscaudDepartment of Toxicology and Biometrology, National Institute for Research and Safety (INRS), rue du Morvan - 54500 Vandœuvre-lès-Nancy, France.
Isabelle LangonnéDepartment of Toxicology and Biometrology, National Institute for Research and Safety (INRS), rue du Morvan - 54500 Vandœuvre-lès-Nancy, France.
Fabrice BattaisDepartment of Toxicology and Biometrology, National Institute for Research and Safety (INRS), rue du Morvan - 54500 Vandœuvre-lès-Nancy, France.
Brigitte LeiningerUniversity of Lorraine, INSERM, UMR-1256, 9 Avenue de la Forêt de Haye - 54500 Vandœuvre-lès-Nancy, France.
Isabelle SponneDepartment of Toxicology and Biometrology, National Institute for Research and Safety (INRS), rue du Morvan - 54500 Vandœuvre-lès-Nancy, France.
Institut National de Recherche et de Sécurité · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms underlying chemical respiratory sensitization are incompletely understood. One of the major cell types involved in this pathology are dendritic cells. In this study, the mechanisms of the NRF2-Keap1 pathway were studied using a bone marrow-derived dendritic cell model exposed to two respiratory sensitizers: ammonium hexachloroplatinate (HCP) and ammonium tetrachloroplatinate (ATCP). Expression levels for two Nrf2-regulated genes,

Indexed as

dendritic cellsflow cytometryNrf2platinum saltrespiratory sensitizer

Identifiers

PMID34956624
PMCPMC8692752
OpenAlexW3215653632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.