Evidence map›Paper›PMID 34956616›Full record

ArticleToxicology research2021

Assessment of toxicological consequences upon acute inhalation exposure to chemically improvised nonlethal riot control combinational formulation (NCF) containing oleoresin capsicum and skatole.

Sanghita Das, Achintya Saha, Pompy Patowary, Pakter Niri, Danswrang Goyary, Sanjeev Karmakar, Pronobesh Chattopadhyay

Abstract read
In one paragraph

Article in Toxicology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sanghita DasDivision of Pharmaceutical Technology, Defence Research Laboratory, Solmara, Tezpur, Assam 784001, India.
Achintya SahaDepartment of Chemical Technology, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, India.
Pompy PatowaryDivision of Pharmaceutical Technology, Defence Research Laboratory, Solmara, Tezpur, Assam 784001, India.
Pakter NiriDivision of Pharmaceutical Technology, Defence Research Laboratory, Solmara, Tezpur, Assam 784001, India.
Danswrang GoyaryDivision of Pharmaceutical Technology, Defence Research Laboratory, Solmara, Tezpur, Assam 784001, India.
Sanjeev KarmakarDivision of Pharmaceutical Technology, Defence Research Laboratory, Solmara, Tezpur, Assam 784001, India.
Pronobesh ChattopadhyayDivision of Pharmaceutical Technology, Defence Research Laboratory, Solmara, Tezpur, Assam 784001, India.ORCID https://orcid.org/0000-0001-7770-6341

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sensory irritation is an acute adverse effect leading to temporary disability posed by riot control agents in various deployable forms are utilized by defense personal in violent mob attacks but their irreversible toxic effects and risk assessment have been a matter of concern. These intimidating risks of available riot control agents have led to exploring the pulmonary toxicity profile of the oil in water emulsion formulation developed for vicious crowd controls containing an irritant oleoresin capsicum, a malodorant (skatole), and a commercial dye, followed by characterization using standard methods. Nonlethal riot control combinational formulation (NCF) has been aimed to be the best possible low-lethal alternative for riot control measures. In this study, 30 min of acute inhalation exposure of NCF was given to Wistar rats and various respiratory parameters like lung dynamics, bronchoalveolar lavage fluid (BALF) cytological assays, pro-inflammatory cytokines estimation, antioxidant activity, collagen accumulation, cytotoxicity,

Indexed as

in vivo lung imagingnonlethal riot control agentsoxidative stresspulmonary toxicity profilingwestern blottingwhole-body plethysmography

Identifiers

PMID34956616
PMCPMC8692724

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.