Evidence map›Paper›PMID 34956570›Full record

ArticleJournal of healthcare engineering2021

Spironolactone Inhibits Cardiomyocyte Hypertrophy by Regulating the Ca

Xin Wang, Wenting Zhang, Jingtao Na, Yanping Huo, Yacheng Wang, Ketong Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of healthcare engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xin WangDepartment of Cardiovascular Medicine, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China.ORCID 0000-0002-0053-7970
Wenting ZhangDepartment of Clinical Pharmacy, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China.ORCID 0000-0002-8231-8527
Jingtao NaDepartment of Cardiovascular Medicine, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China.ORCID 0000-0001-9422-1602
Yanping HuoDepartment of Cardiovascular Medicine, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China.ORCID 0000-0003-1468-9702
Yacheng WangThe Ultrasound Department, The Second Hospital of Qiqihar, Qiqihar 161000, China.ORCID 0000-0002-6958-2251
Ketong LiuDepartment of Cardiovascular Medicine, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China.ORCID 0000-0003-3020-7275
Qiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the protective effect and molecular mechanism of spironolactone in isoproterenol-induced cardiomyocyte hypertrophy. In this study, primary cardiomyocytes were extracted from the heart of neonatal rats. After stable culture, they were processed with isoproterenol alone or isoproterenol (10

Indexed as

CalcineurinMyocytes, CardiacSpironolactoneAnimalsCalciumHypertrophyNFATC Transcription FactorsRatsCalcineurinCalciumNFATC Transcription FactorsSpironolactonetranscription factor NF-AT c3

Identifiers

PMID34956570
PMCPMC8702305
OpenAlexW4200058606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.