Evidence map›Paper›PMID 34956483›Full record

ArticleAmerican journal of translational research2021

Laminin alpha-3 and thrombospondin-1 differently regulate the survival and differentiation of hepatocytes and hepatic stem cells from neonatal mice.

Shuai Zhang, Heba E Sharaf Eldin, Wei-Li Gu, Tao-Sheng Li

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Shuai ZhangDepartment of Hepatopancreatobiliary Surgery, Guangzhou First People's Hospital Guangzhou 510180, China.
Heba E Sharaf EldinDepartment of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Wei-Li GuDepartment of Hepatopancreatobiliary Surgery, Guangzhou First People's Hospital Guangzhou 510180, China.
Tao-Sheng LiDepartment of Stem Cell Biology, Atomic Bomb Disease Institute, Nagasaki University 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Guangzhou First People's Hospital · CNNagasaki University · JPTanta University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to search and identify the extracellular matrix/adhesion molecules potentially regulating liver regeneration. By using pathway-focused PCR array, we investigated the dynamic changes in the expression of extracellular matrix and adhesion molecules in normal livers or cholestatic livers following partial hepatectomy in adult mice. To confirm the data from PCR array, we further evaluated how laminin alpha-3 and thrombospondin-1 mediate the survival and differentiation of matured hepatocytes and immature hepatic stem cells by using primarily isolated liver cells from neonatal mice. According to the different changes in the expression of extracellular matrix and adhesion molecules between normal livers and cholestatic livers, we could find a number of potential molecules involved in liver regeneration. Our

Indexed as

differentiationhepatic stem cellsLaminin alpha-3survivalthrombospondin-1

Identifiers

PMID34956483
PMCPMC8661240
OpenAlexW4206852704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.