Evidence map›Paper›PMID 34956480›Full record

ArticleAmerican journal of translational research2021

Maternal Vit D supplementation in AMA mice and the role of Vit D/VDR signaling in the offspring's cognition.

Dao Li, Yawen Xu, Kai Wang, Zhuanhong Yang, Hui Li, Sijia Lei, Suqing Wang

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dao LiDepartment of Preventive Medicine, School of Health Sciences, Wuhan University Wuhan 430071, Hubei, China.
Yawen XuDepartment of Preventive Medicine, School of Health Sciences, Wuhan University Wuhan 430071, Hubei, China.
Kai WangDepartment of Preventive Medicine, School of Health Sciences, Wuhan University Wuhan 430071, Hubei, China.
Zhuanhong YangDepartment of Preventive Medicine, School of Health Sciences, Wuhan University Wuhan 430071, Hubei, China.
Hui LiDepartment of Preventive Medicine, School of Health Sciences, Wuhan University Wuhan 430071, Hubei, China.
Sijia LeiGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University Guangzhou 510275, Guangdong, China.
Suqing WangDepartment of Preventive Medicine, School of Health Sciences, Wuhan University Wuhan 430071, Hubei, China.
Wuhan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the molecular mechanism underlying the effect of maternal vitamin D (Vit D) supplementation before pregnancy in advanced maternal age (AMA) mice on the offspring's cognitive function.

methodsThirty-two-week-old female mice either received 10 IU/g body weight vitamin D

resultsVit D intervention markedly improved the serum 1,25 dihydroxy vitamin D

conclusionOur findings highlight the biological significance of maternal Vit D supplementation before pregnancy on Vit D metabolism, and signaling molecules in the offspring, underlying the potential mechanism of the cognitive impairment in the offspring born to AMA mice.

Indexed as

advance maternal ageHIF-1α/VEGFsynaptic biomarkersVDRVitamin D supplementation

Identifiers

PMID34956480
PMCPMC8661169
OpenAlexW4206871291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.