Knockout of Bruton's tyrosine kinase in macrophages attenuates diabetic nephropathy in streptozotocin-induced mice.

Zhe Fan, Yuanyuan Li, Lingling Xia, Yonggui Wu

Open access · greenAbstract read

In one paragraph

Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Inhibition of BTK and PI3Kδ impairs the development of human JMML stem and progenitor cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhe FanDepartment of Nephropathy, The First Affiliated Hospital of Anhui Medical University Hefei 230032, Anhui, China.

Yuanyuan LiDepartment of Nephropathy, The First Affiliated Hospital of Anhui Medical University Hefei 230032, Anhui, China.

Lingling XiaDepartment of Infective Disease, The First Affiliated Hospital of Anhui Medical University Hefei 230032, Anhui, China.

Yonggui WuDepartment of Nephropathy, The First Affiliated Hospital of Anhui Medical University Hefei 230032, Anhui, China.

Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a cytoplasmic tyrosine kinase in the Tec family, Bruton's tyrosine kinase (Btk) participates in various biological processes, including cell growth, differentiation, and apoptosis. Although recent studies have indicated that Btk is involved in pro-inflammatory cytokine production, the underlying impact of Btk on the development and pathogenesis of diabetic nephropathy (DN) has not been elucidated. The aim of this study was to determine whether Btk knockout (KO) could reduce inflammation and kidney injury in DN. First, diabetic mice models were established via an intraperitoneal injection of streptozotocin. Thereafter, the underlying mechanism was explored by comparing

Indexed as

Bruton’s tyrosine kinasesDiabetic nephropathyinflammationmacrophage

Identifiers

PMID34956457

PMCPMC8661227

OpenAlexW4206874773

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.