Evidence map›Paper›PMID 34956424›Full record

ArticleThe EPMA journal2021

Early gestational profiling of oxidative stress and angiogenic growth mediators as predictive, preventive and personalised (3P) medical approach to identify suboptimal health pregnant mothers likely to develop preeclampsia.

Enoch Odame Anto, David Antony Coall, Otchere Addai-Mensah, Yaw Amo Wiafe, William K B A Owiredu, Christian Obirikorang, Max Efui Annani-Akollor, Eric Adua, Augustine Tawiah, Emmanuel Acheampong and 8 more

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In one paragraph

Article in The EPMA journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 3 countries.

Enoch Odame AntoDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
David Antony CoallCentre for Precision Health, Edith Cowan University, Perth, Australia.
Otchere Addai-MensahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Yaw Amo WiafeDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
William K B A OwireduDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Christian ObirikorangDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Max Efui Annani-AkollorDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Eric AduaCentre for Precision Health, Edith Cowan University, Perth, Australia.
Augustine TawiahDepartment of Obstetrics and Gynaecology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Emmanuel AcheampongDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Evans Adu AsamoahDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Xueqing WangCentre for Precision Health, Edith Cowan University, Perth, Australia.
Stephen OpokuDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Derick Kyei BoakyeDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Haifeng HouCentre for Precision Health, Edith Cowan University, Perth, Australia.
Youxin WangCentre for Precision Health, Edith Cowan University, Perth, Australia.
Wei WangCentre for Precision Health, Edith Cowan University, Perth, Australia.ORCID 0000-0002-1430-1360
Suboptimal Health Study Consortium (SHSC)
Kwame Nkrumah University of Science and Technology · GHEdith Cowan University · AUKomfo Anokye Teaching Hospital · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsA prospective cohort of 593 singleton normotensive pregnant (NTN-P) women were recruited at 10-20th (visit 1) and followed from 21 weeks gestation until the time of PE diagnosis and delivery. At visit 1, SHS was assessed using SHS questionnaire-25 (SHSQ-25) and women were classified as SHS and optimal health status (OHS). Biomarkers of OS (8-hydroxy-2-deoxyguanosine [8-OHdG], 8-epi-prostaglansinF2alpha [8-epi-PGF2α] and total antioxidant capacity [TAC]) and AGMs (vascular endothelial growth factor [VEGF-A], soluble Fms-like tyrosine kinase-1 [sFlt-1], placental growth factor [PlGF] and soluble endoglin [sEng]) were measured at visit 1 and time of PE diagnosis.

resultsOf the 593 mothers, 498 (248 SHS and 250 OHS) returned for delivery and were included in the final analysis. Fifty-six, 97 and 95 of the 248 SHS mothers developed EO-PE, LO-PE and NTN-P respectively, versus 14 EO-PE, 30 LO-PE and 206 NTN-P among the 250 OHS mothers. At the 10-20th week gestation, unbalanced levels of OS and AGMs were observed among SHS women who developed EO-PE than LO-PE compared to NTN-P women (

conclusionUnlike OHS pregnant women, SHS pregnant women have high incidence of PE coupled with unbalanced levels of OS and AGMs at 10-20 weeks gestation. Combining early gestational profiling of OS and AGMs created an avenue for early differentiation of PE subtypes in the context of 3 PM care for mothers at high risk of PE.

Indexed as

Angiogenic growth mediatorsOxidative stressPredictive preventive personalised medicine (3P/PPPM)PreeclampsiaRisk assessment, Treatment algorithm, Patient stratification, Maternal health care, Public health educationSuboptimal health status

Identifiers

PMID34956424
PMCPMC8648887
OpenAlexW3209720930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.