Evidence map›Paper›PMID 34956419›Full record

SynthesisDisease markers2021

Was Antiphospholipid Syndrome a Risk Factor of Stroke? A Systemic Review and Meta-Analysis of Cohort Studies.

Kai Zhao, Ping Zhou, Ling Xu, Ruili Li, Jincai Yang, Qiang Zhang, Mingfei Yang, Xiaoxing Wei

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Young stroke: An update on epidemiology, emerging risk factors, and future research directions.International journal of stroke : official journal of the International Stroke Society · 2026
    Review
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kai ZhaoGraduate School, Qinghai University, Xining, Qinghai 810016, China.
Ping ZhouDepartment of Neurosurgery, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, China.
Ling XuDepartment of Community Health Education, Institute for Health Education of Qinghai Province, Xining, Qinghai 810000, China.
Ruili LiDepartment of Neurological Intensive Care, Shengli Oilfield Central Hospital, Dongying, Shandong 257000, China.
Jincai YangGraduate School, Qinghai University, Xining, Qinghai 810016, China.
Qiang ZhangDepartment of Neurosurgery, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, China.
Mingfei YangDepartment of Neurosurgery, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, China.ORCID https://orcid.org/0000-0002-0447-1470
Xiaoxing WeiMedical College of Qinghai University, Xining, Qinghai 810016, China.ORCID https://orcid.org/0000-0002-8861-9769
Qinghai Provincial Peoples Hospital · CNQinghai University · CNShengli Oilfield Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antiphospholipid syndrome (APS) is characterized by thrombosis. This systemic review and meta-analysis was to verify the hypothesis that APS might increase the risk of stroke. Studies were identified after literature searching of PubMed, Embase, and Cochrane. Newcastle-Ottawa Quality Assessment Scale Cohort Studies (NOQAS-C) was used to assess the quality of studies. The pooled effect with 95% confidence interval (95% CI) was calculated by random-effect model.

Indexed as

Antiphospholipid SyndromeCohort StudiesHumansRecurrenceRisk FactorsStrokeThrombosis

Identifiers

PMID34956419
PMCPMC8702362
OpenAlexW4200371457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.