Evidence map›Paper›PMID 34956401›Full record

ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS2021

Transmission Jeopardy of Adenomatosis Polyposis Coli and Methylenetetrahydrofolate Reductase in Colorectal Cancer.

Younis Mohd, Parvinder Kumar, Haripriya Kuchi Bhotla, Arun Meyyazhagan, Balamuralikrishnan Balasubramanian, Mithun Kumar Ramesh Kumar, Manikantan Pappusamy, Karthick Kumar Alagamuthu, Antonio Orlacchio, Sasikala Keshavarao and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the renin-angiotensin-aldosterone system : JRAAS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Younis MohdMedical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, School of Life Sciences, Bharathiar University, 641046 Tamil Nadu, India.
Parvinder KumarDepartment of Zoology, Jammu University, Jammu, 180006 Jammu and Kashmir, India.
Haripriya Kuchi BhotlaHuman Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 461046 Tamil Nadu, India.ORCID https://orcid.org/0000-0002-9997-6454
Arun MeyyazhaganDepartment of Life Sciences, CHRIST (Deemed to be University), Bangalore 560029, India.ORCID https://orcid.org/0000-0002-1934-3906
Balamuralikrishnan BalasubramanianDepartment of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul 05006, Republic of Korea.ORCID https://orcid.org/0000-0001-6938-1495
Mithun Kumar Ramesh KumarDepartment of General Surgery, Mahatma Gandhi Medical College and Research Institute, Pillaiyarkuppam, 607403 Pondicherry, India.
Manikantan PappusamyDepartment of Life Sciences, CHRIST (Deemed to be University), Bangalore 560029, India.ORCID https://orcid.org/0000-0002-6047-3702
Karthick Kumar AlagamuthuDepartment of Biotechnology, Selvamm Arts and Science College (Autonomous), Namakkal, Tamil Nadu 637003, India.
Antonio OrlacchioLaboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello (CERC), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy.ORCID https://orcid.org/0000-0002-2602-3281
Sasikala KeshavaraoHuman Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 461046 Tamil Nadu, India.
Palanisamy SampathkumarDepartment of Chemistry and Biosciences, SASTRA Deemed to be University, Kumbakonam Tamil Nadu 612001, India.
Vijaya Anand ArumugamMedical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, School of Life Sciences, Bharathiar University, 641046 Tamil Nadu, India.ORCID https://orcid.org/0000-0001-7485-1586
Bharathiar University · INDepartment of Biotechnology · INMahatma Gandhi Medical College and Research Institute · INUniversity of Jammu · INUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is one of the globally prevalent and virulent types of cancer with a distinct alteration in chromosomes. Often, any alterations in the adenomatosis polyposis coli (APC), a tumor suppressor gene, and methylenetetrahydrofolate reductase (MTHFR) gene are related to surmise colorectal cancer significantly. In this study, we have investigated chromosomal and gene variants to discern a new-fangled gene and its expression in the southern populations of India by primarily spotting the screened APC and MTHFR variants in CRC patients. An equal number of CRC patients and healthy control subjects (

Indexed as

Colorectal NeoplasmsAdenomatous Polyposis Coli ProteinGenetic Predisposition to DiseaseGenotypeHumansMethylenetetrahydrofolate Reductase (NADPH2)Polymorphism, GeneticRisk FactorsAdenomatous Polyposis Coli ProteinAPC protein, humanMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, human

Identifiers

PMID34956401
PMCPMC8683247
OpenAlexW4200169260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.