Evidence map›Paper›PMID 34956378›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2021

Protective Effect of NGR1 against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells by Upregulating the SIRT1/Wnt/

Dong Wang, Bibo Gao, Tao Yang, Huiying Sun, Xiaoping Ran, Wen Lin

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Notoginsenoside R1, a Metabolite fromMolecules (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dong WangDepartment of Neurological Diseases, Ziyang People's Hospital of Sichuan Province, Ziyang, Sichuan 641300, China.
Bibo GaoDepartment of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650030, China.
Tao YangDepartment of Neurosurgery, The General Hospital of Western Theater Command, Chengdu, Sichuan 610000, China.
Huiying SunDepartment of Neurological Diseases, Ziyang People's Hospital of Sichuan Province, Ziyang, Sichuan 641300, China.
Xiaoping RanDepartment of Neurological Diseases, Ziyang People's Hospital of Sichuan Province, Ziyang, Sichuan 641300, China.
Wen LinDepartment of Neurological Diseases, Ziyang People's Hospital of Sichuan Province, Ziyang, Sichuan 641300, China.ORCID https://orcid.org/0000-0003-0193-3315
Kunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Notoginsenoside R1 (NGR1) is an active compound isolated from

Identifiers

PMID34956378
PMCPMC8694997
OpenAlexW4200608077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.