Evidence map›Paper›PMID 34956237›Full record

ArticleFrontiers in immunology2021

Single-Domain Antibodies for Targeting, Detection, and

Bjoern Traenkle, Philipp D Kaiser, Stefania Pezzana, Jennifer Richardson, Marius Gramlich, Teresa R Wagner, Dominik Seyfried, Melissa Weldle, Stefanie Holz, Yana Parfyonova and 12 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Selective Immune Silencing by Targeted TGF-β Agonists.bioRxiv : the preprint server for biology · 2026
    Article
  6. Reengineered Anti-CD4 Cys-diabody Variants forMolecular imaging and biology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Imaging Inflammation Past, Present, and Future: Focus on Cardioimmunology.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  19. Advances in PET imaging of cancer.Nature reviews. Cancer · 2023
    Review
  20. Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Bjoern TraenkleNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
Philipp D KaiserNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
Stefania PezzanaWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen, Germany.
Jennifer RichardsonDepartment of Immunology, Institute of Cell Biology, University of Tübingen, Tübingen, Germany.
Marius GramlichNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
Teresa R WagnerNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
Dominik SeyfriedWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen, Germany.
Melissa WeldlePharmaceutical Biotechnology, University of Tübingen, Tübingen, Germany.
Stefanie HolzPharmaceutical Biotechnology, University of Tübingen, Tübingen, Germany.
Yana ParfyonovaPharmaceutical Biotechnology, University of Tübingen, Tübingen, Germany.
Stefan NueskeLivestock Center of the Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Oberschleissheim, Germany.
Armin M ScholzLivestock Center of the Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Oberschleissheim, Germany.
Anne ZeckNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
Meike JakobiNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
Nicole Schneiderhan-MarraNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
Martin SchallerDepartment of Dermatology, University of Tübingen, Tübingen, Germany.
Andreas MaurerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen, Germany.
Cécile GouttefangeasDepartment of Immunology, Institute of Cell Biology, University of Tübingen, Tübingen, Germany.
Manfred KneillingWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen, Germany.
Bernd J PichlerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen, Germany.
Dominik SonaniniWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen, Germany.
Ulrich RothbauerNMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advancement of new immunotherapies necessitates appropriate probes to monitor the presence and distribution of distinct immune cell populations. Considering the key role of CD4

Indexed as

Single-Domain AntibodiesAnimalsCD4-Positive T-LymphocytesHeterograftsHumansMiceMolecular ImagingOptical ImagingSingle-Domain AntibodiesCD4immune tracerimmunotherapiesmagnetic resonance imagingnanobodyPET imaging

Identifiers

PMID34956237
PMCPMC8696186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.