Evidence map›Paper›PMID 34956139›Full record

ArticleFrontiers in microbiology2021

Viral Evasion of Innate Immune Defense: The Case of Resistance of Pandemic H1N1 Influenza A Virus to Human Mannose-Binding Proteins.

Mitchell R White, Nikolaos M Nikolaidis, Francis McCormack, Erika C Crouch, Kevan L Hartshorn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mitchell R WhiteDepartment of Medicine, Section of Hematology and Oncology, School of Medicine, Boston University, Boston, MA, United States.
Nikolaos M NikolaidisDivision of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH, United States.
Francis McCormackDivision of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH, United States.
Erika C CrouchDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Kevan L HartshornDepartment of Medicine, Section of Hematology and Oncology, School of Medicine, Boston University, Boston, MA, United States.
Washington University in St. Louis · USBoston University · US

Funding

Pulmonary Epithelial Dynamics and Innate Host DefenseR01HL135122 · NHLBI · UNIVERSITY OF CINCINNATI · PI MCCORMACK, FRANCIS XAVIER · 2018 to 2021
$2.0M
NHLBI NIH HHS R01 HL135122
6 · The paper itself

Abstract

Mannose-binding lectins effectively inhibit most seasonal strains of influenza A virus and contribute to the innate host defense vs. these viruses. In contrast, pandemic IAV strains are largely resistant to these lectins, likely contributing to increased spread and worse outcomes. In this paper, we evaluated the inhibition of IAV by mannose-binding lectins of human, bacterial, and fungal origin to understand and possibly increase activity vs. the pandemic IAV. A modified version of the human surfactant protein D (SP-D) neck and carbohydrate recognition domain (NCRD) with combinatorial substitutions at the 325 and 343 positions, previously shown to inhibit pandemic H3N2 IAV

Indexed as

cyanovirinhemagglutininfluenzamannose binding lectin (MBL)Surfactant protein (SP-D)

Identifiers

PMID34956139
PMCPMC8692257
OpenAlexW4200376107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.