Evidence map›Paper›PMID 34956071›Full record

ArticleFrontiers in neurology2021

Erenumab for Migraine Prevention in a 1-Year Compassionate Use Program: Efficacy, Tolerability, and Differences Between Clinical Phenotypes.

Jean Schoenen, Gregory Timmermans, Romain Nonis, Maïté Manise, Arnaud Fumal, Pascale Gérard

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05442008 completednot on this map

Study of Early MIDAS Reduction at 3 Months as Predictor of Long-term Erenumab Treatment in Chronic Migraine: a Real-life, Open-label, Trial

TypeobservationalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2018 to 2021Enrolled53ConditionsMigraineArmsErenumab 70/140 mg s.c.
NCT06109389 phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

The Efficacy of Intravenous Lidocaine Infusion in Chronic Unilateral Migraine Headache Clinical and Laboratory Assessment .Aprospective Randomized Double Blind Controlled Study

TypeinterventionalSponsorAlexandria UniversityRan2023 to 2024Enrolled80ConditionsChronic Migraine, HeadacheArmsLidocaine IV
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Calcitonin gene-related peptide causes migraine aura.The journal of headache and pain · 2023
    Article
  12. Review
  13. Predictors of response to galcanezumab in patients with chronic migraine: a real-world prospective observational study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Observational
  14. Article
  15. Article
  16. Review
  17. The ultimate guide to the anti-CGRP monoclonal antibodies galaxy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Review
  18. Observational
  19. Dural Immune Cells, CGRP, and Migraine.Frontiers in neurology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jean SchoenenHeadache Research Unit, Department of Neurology, Citadelle Hospital-Liège, University of Liège, Liège, Belgium.
Gregory TimmermansHeadache Research Unit, Department of Neurology, Citadelle Hospital-Liège, University of Liège, Liège, Belgium.
Romain NonisHeadache Research Unit, Department of Neurology, Citadelle Hospital-Liège, University of Liège, Liège, Belgium.
Maïté ManiseHeadache Research Unit, Department of Neurology, Citadelle Hospital-Liège, University of Liège, Liège, Belgium.
Arnaud FumalHeadache Research Unit, Department of Neurology, Citadelle Hospital-Liège, University of Liège, Liège, Belgium.
Pascale GérardHeadache Research Unit, Department of Neurology, Citadelle Hospital-Liège, University of Liège, Liège, Belgium.
Centre hospitalier régional de la Citadelle · BEUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During a 1-year compassionate use program, 156 patients with migraine self-administered a monthly dose of erenumab 140 mg with a subcutaneous autoinjector. Main inclusion criteria were: ≥ 4 migraine days/month and ≥two prior prophylactic treatment failures. The patients covered the migraine severity spectrum from episodic migraine (EM) (

Indexed as

compassionate useerenumabmigraine prophylaxismonoclonal antibodies blocking CGRP transmissionoutcome predictors

Identifiers

PMID34956071
PMCPMC8703164
OpenAlexW4200628345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.