ArticleFrontiers in neurology2021
The Differential Effects of Acute Right- vs. Left-Sided Vestibular Deafferentation on Spatial Cognition in Unilateral Labyrinthectomized Mice.
Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Galvanic vestibular stimulation promotes visuospatial cognitive recovery in acute unilateral vestibulopathy via targeted neural modulation: a randomized controlled trial.Journal of translational medicine · 2025Trial
- Symptom and Handicap Severity in Subacute Dizzy Patients: The Role of Gaze Position Error in Video Head Impulses.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025Article
- Impairment of human spatial orientation in the horizontal, but not the vertical plane, due to aging, cognitive decline, or chronic peripheral vestibular loss.Frontiers in aging neuroscience · 2025Article
- Normal visuospatial function in unilateral vestibulopathy: on the challenge of group differences within normal reference data.Frontiers in neurology · 2023Article
- Visuospatial cognition in acute unilateral peripheral vestibulopathy.Frontiers in neurology · 2023Article
- The Effect of Galvanic Vestibular Stimulation on Visuospatial Cognition in an Incomplete Bilateral Vestibular Deafferentation Mouse Model.Frontiers in neurology · 2022Article
- Recent developments in the understanding of the interactions between the vestibular system, memory, the hippocampus, and the striatum.Frontiers in neurology · 2022Review
- Thresholds for vestibular and cutaneous perception and oculomotor response induced by galvanic vestibular stimulation.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the disparity in locomotor and spatial memory deficits caused by left- or right-sided unilateral vestibular deafferentation (UVD) using a mouse model of unilateral labyrinthectomy (UL) and to examine the effects of galvanic vestibular stimulation (GVS) on the deficits over 14 days. Five experimental groups were established: the left-sided and right-sided UL (Lt.-UL and Rt.-UL) groups, left-sided and right-sided UL with bipolar GVS with the cathode on the lesion side (Lt.-GVS and Rt.-GVS) groups, and a control group with sham surgery. We assessed the locomotor and cognitive-behavioral functions using the open field (OF), Y maze, and Morris water maze (MWM) tests before (baseline) and 3, 7, and 14 days after surgical UL in each group. On postoperative day (POD) 3, locomotion and spatial working memory were more impaired in the Lt.-UL group compared with the Rt.-UL group (
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