ArticleFrontiers in physiology2021
On the Potential Self-Amplification of Aneurysms Due to Tissue Degradation and Blood Flow Revealed From FSI Simulations.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 28 citations in OpenAlex.
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- Local pressure as a dominant hemodynamic driver of wall enhancement in anterior communicating artery aneurysms: a facet-level computational fluid dynamics and vessel wall imaging analysis.Quantitative imaging in medicine and surgery · 2026Article
- Advances in Functional Vascular Stents for Cardiovascular Therapy with Drug Delivery and Computational Design.Pharmaceutics · 2026Review
- Impact of geometric factors and shear stress on endothelial function: Hemodynamic insights from human cerebral arterial bifurcations.Physiological reports · 2026Article
- A multi-fractal vascular tree model for characterizing blood flow in cardiovascular system.Scientific reports · 2026Article
- Alterations in ascending aortic hemodynamics and aortic length correlate with sex-specific thoracic aortic aneurysm dilation and lifespan in a mouse model of severe Marfan syndrome.Computers in biology and medicine · 2026Article
- Computational fluid dynamics analysis of hemodynamics in bicuspid aortic valve with giant aneurysm.Journal of cardiothoracic surgery · 2026Article
- Hemodynamic response to stent-induced aneurysm deformation in patient-specific internal carotid artery cases: A computational study.Scientific reports · 2025Article
- Hemodynamic characterization of spontaneous isolated superior mesenteric artery dissection revealed by patient-specific computational fluid dynamics.Biomedical engineering online · 2025Article
- Comprehensive morphomechanical and wall enhancement analysis of intracranial aneurysms.European radiology · 2025Article
- Impact of anatomical variations of the circle of Willis on the blood flow within unruptured intracranial aneurysm.Quantitative imaging in medicine and surgery · 2025Article
- Hemodynamic analysis of thrombosed intracranial aneurysms: a comparative correlation study.Neurosurgical review · 2025Article
- Computational assessment of blood lipid influence on hemodynamics in human retinal vessels.Scientific reports · 2025Article
- Maximum admittance method for cerebrovascular outlet boundary conditions and importance of stenosis severity as a dominant factor on hemodynamics.Scientific reports · 2025Article
- Anatomical location-related hemodynamic variations are associated with atherosclerosis in the middle cerebral artery: a preliminary cross-sectional 4D flow and 3D vessel wall MRI study.Quantitative imaging in medicine and surgery · 2025Article
- Study of blood flow patterns in a stenosed artery through the combined effect of body acceleration and generalized womersley solution.Scientific reports · 2025Article
- Plasma exosomes from patients with coronary artery disease promote atherosclerosis via impairing vascular endothelial junctions.Scientific reports · 2024Article
- On flow fluctuations in ruptured and unruptured intracranial aneurysms: resolved numerical study.Scientific reports · 2024Article
- Virtual Planning and Patient-Specific Graft Design for Aortic Repairs.Cardiovascular engineering and technology · 2024Article
- Analysis of Intracranial Aneurysm Haemodynamics Altered by Wall Movement.Bioengineering (Basel, Switzerland) · 2024Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue degradation plays a crucial role in the formation and rupture of aneurysms. Using numerical computer simulations, we study the combined effects of blood flow and tissue degradation on intra-aneurysm hemodynamics. Our computational analysis reveals that the degradation-induced changes of the time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) within the aneurysm dome are inversely correlated. Importantly, their correlation is enhanced in the process of tissue degradation. Regions with a low TAWSS and a high OSI experience still lower TAWSS and higher OSI during degradation. Furthermore, we observed that degradation leads to an increase of the endothelial cell activation potential index, in particular, at places experiencing low wall shear stress. These findings are robust and occur for different geometries, degradation intensities, heart rates and pressures. We interpret these findings in the context of recent literature and argue that the degradation-induced hemodynamic changes may lead to a self-amplification of the flow-induced progressive damage of the aneurysmal wall.
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