Evidence map›Paper›PMID 34955757›Full record

ArticleFrontiers in cellular neuroscience2021

Retinal Organoids Long-Term Functional Characterization Using Two-Photon Fluorescence Lifetime and Hyperspectral Microscopy.

Yuntian Xue, Andrew W Browne, William C Tang, Jeffrey Delgado, Bryce T McLelland, Gabriel Nistor, Jacqueline T Chen, Kaylee Chew, Nicolas Lee, Hans S Keirstead and 1 more

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. The Prospects for Retinal Organoids in Treatment of Retinal Diseases.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuntian XueDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Andrew W BrowneDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
William C TangDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Jeffrey DelgadoStem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Bryce T McLellandAIVITA Biomedical, Inc., Irvine, CA, United States.
Gabriel NistorAIVITA Biomedical, Inc., Irvine, CA, United States.
Jacqueline T ChenStem Cell Research Center, University of California, Irvine, Irvine, CA, United States.
Kaylee ChewDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Nicolas LeeDepartment of Physics and Astronomy, University of California, Irvine, Irvine, CA, United States.
Hans S KeirsteadAIVITA Biomedical, Inc., Irvine, CA, United States.
Magdalene J SeilerStem Cell Research Center, University of California, Irvine, Irvine, CA, United States.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING · 2007 to 2016
$25.1M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
PacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600k
High-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600k
High Throughput DNA SequencerS10RR025496 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2009 to 2009
$500k
NCATS NIH HHS KL2 TR001416NCI NIH HHS P30 CA062203NCRR NIH HHS S10 RR025496NIGMS NIH HHS P50 GM076516NIH HHS S10 OD010794NIH HHS S10 OD021718
6 · The paper itself

Abstract

Pluripotent stem cell-derived organoid technologies have opened avenues to preclinical basic science research, drug discovery, and transplantation therapy in organ systems. Stem cell-derived organoids follow a time course similar to species-specific organ gestation

Indexed as

fluorescence lifetime imagingfunctional imaginghuman embryonic stem cellhyperspectral imagingretinal organoidssingle cell RNA sequencingtwo-photon microscopy

Identifiers

PMID34955757
PMCPMC8707055

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.