Evidence map›Paper›PMID 34955735›Full record

ReviewFrontiers in neuroscience2021

Sensory Circuit Remodeling and Movement Recovery After Spinal Cord Injury.

Yunuen Moreno-López, Edmund R Hollis

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yunuen Moreno-LópezBurke Neurological Institute, White Plains, NY, United States.
Edmund R HollisBurke Neurological Institute, White Plains, NY, United States.
Burke Medical Research Institute · USCornell University · US

Funding

Optical Dissection of Intracortical Circuits Supporting Motor Recovery After Spinal Cord InjuryR01NS105725 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI HOLLIS, EDMUND R · 2019 to 2023
$2.3M
NINDS NIH HHS R01 NS105725
6 · The paper itself

Abstract

Restoring sensory circuit function after spinal cord injury (SCI) is essential for recovery of movement, yet current interventions predominantly target motor pathways. Integrated cortical sensorimotor networks, disrupted by SCI, are critical for perceiving, shaping, and executing movement. Corticocortical connections between primary sensory (S1) and motor (M1) cortices are critical loci of functional plasticity in response to learning and injury. Following SCI, in the motor cortex, corticocortical circuits undergo dynamic remodeling; however, it remains unknown how rehabilitation shapes the plasticity of S1-M1 networks or how these changes may impact recovery of movement.

Indexed as

corticocorticalcorticospinalmovement recoveryrehabilitationspinal cord injury

Identifiers

PMID34955735
PMCPMC8692650
OpenAlexW4200479600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.