Evidence map›Paper›PMID 34955677›Full record

ReviewBiochemia medica2022

Deviating glucose results in an international dual-center study. A root cause investigation.

Janne Cadamuro, Peter Bergsten, Katharina Mörwald, Anders Forslund, Marie Dahlbom, Jonas Bergquist, Iris Ciba, Susanne M Brunner, Jeanne Jabbour, Daniel Weghuber

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemia medica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Janne CadamuroDepartment of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
Peter BergstenDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Katharina MörwaldPediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
Anders ForslundDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Marie DahlbomDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Jonas BergquistAnalytical Chemistry and Neurochemistry, Department of Chemistry - Biomedical Center, Uppsala University, Uppsala, Sweden.
Iris CibaDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Susanne M BrunnerDepartment of Pediatrics, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
Jeanne JabbourPediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
Daniel WeghuberPediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
Paracelsus Medical University · ATUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During a dual-center study on obese and normal weight children and adolescents, focusing on glucose metabolism, we observed a marked difference in glucose results (N = 16,840) between the two sites, Salzburg, Austria and Uppsala, Sweden (P < 0.001). After excluding differences in patient characteristics between the two populations as cause of this finding, we investigated other preanalytic influences. Finally, only the tubes used for blood collection at the two sites were left to evaluate. While the Vacuette FC-Mix tube (Greiner Bio-One, Kremsmünster, Austria) was used in Uppsala, in Salzburg blood collections were performed with a lithium heparin tube (LH-Monovette, Sarstedt, Germany). To prove our hypothesis, we collected two blood samples in either of these tubes from 51 children (Salzburg N = 27, Uppsala N = 24) and compared the measured glucose results. Indeed, we found the suspected bias and calculated a correction formula, which significantly diminished the differences of glucose results between the two sites (

Indexed as

Blood Specimen CollectionGlucoseAdolescentBlood GlucoseChildEuropeHeparinHumansBlood GlucoseGlucoseHeparinblood collection tubespreanalytical errorpreanalytical phasePREDICTtube additive

Identifiers

PMID34955677
PMCPMC8672384
OpenAlexW4200042219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.