Observational studyBritish journal of anaesthesia2022
Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients: prospective observational study in European intensive care units.
Observational study in British journal of anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes and Prognostic Factors in Coronavirus Disease (COVID-19) in Very Old Intensive Care Patients
Comparison Between Early and Late Tracheostomy in ICU Patients Including Non-Covid and Covid Patients, an Observational Cohort Study at SQUH
Observational iNternational Study of TRACHeostomy Practice in Adult Intensive Care Units - ON TRACH
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- High-flow nasal oxygen versus conventional oxygen therapy and noninvasive ventilation in COVID-19 respiratory failure: a systematic review and network meta-analysis of randomised controlled trials.British journal of anaesthesia · 2024Pooled it
- Early versus late tracheostomy in critically ill COVID-19 patients.The Cochrane database of systematic reviews · 2023Pooled it
- Long-Term Communicative Experiences of Tracheostomised Patients 1 Year After Hospital Discharge: A Mixed Methods Study.Journal of clinical nursing · 2026Observational
- Analysis of the External Validity of the RAISE Score for Prediction of Prolonged Mechanical Ventilation in a United States-Based Cohort of Subarachnoid Hemorrhage Patients.Neurocritical care · 2026Article
- Percutaneous tracheostomy procedures and patient results in a tertiary intensive care unit: A single-center experience.Medicine · 2025Observational
- Association between Tracheostomy Timing and Clinical Outcomes in Critically Ill COVID19 Patients.Iranian journal of otorhinolaryngology · 2025Article
- Tracheostomy is associated with decreased in-hospital mortality during severe COVID-19 infection.World journal of otorhinolaryngology - head and neck surgery · 2024Article
- Article
- The Effect of Comorbidities and Complications on COVID-19 Mortality: A Detailed Retrospective Study in Western Romania.Journal of personalized medicine · 2023Article
- Patient-Centred Outcomes Following Tracheostomy in Critical Care.Journal of intensive care medicine · 2023Article
- Predictors of Mortality in Patients With COVID-19 Undergoing Tracheotomy.The Annals of otology, rhinology, and laryngology · 2023Article
- Outcomes of Early Versus Late Tracheostomy in Patients With COVID-19: A Multinational Cohort Study.Critical care explorations · 2022Article
- What factors predict craniomandibular disorders in severe COVID-19 survivors after prolonged intubation?Journal of stomatology, oral and maxillofacial surgery · 2022Article
- The Impact of Different Ventilatory Strategies on Clinical Outcomes in Patients with COVID-19 Pneumonia.Journal of clinical medicine · 2022Article
- Tracheostomy timing and outcomes in patients with coronavirus disease 2019-associated acute respiratory distress syndrome: A retrospective observational study.International journal of critical illness and injury scienceArticle
Corrections and comments
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Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTracheostomy is performed in patients expected to require prolonged mechanical ventilation, but to date optimal timing of tracheostomy has not been established. The evidence concerning tracheostomy in COVID-19 patients is particularly scarce. We aimed to describe the relationship between early tracheostomy (≤10 days since intubation) and outcomes for patients with COVID-19.
methodsThis was a prospective cohort study performed in 152 centres across 16 European countries from February to December 2020. We included patients aged ≥70 yr with confirmed COVID-19 infection admitted to an intensive care unit, requiring invasive mechanical ventilation. Multivariable analyses were performed to evaluate the association between early tracheostomy and clinical outcomes including 3-month mortality, intensive care length of stay, and duration of mechanical ventilation.
resultsThe final analysis included 1740 patients with a mean age of 74 yr. Tracheostomy was performed in 461 (26.5%) patients. The tracheostomy rate varied across countries, from 8.3% to 52.9%. Early tracheostomy was performed in 135 (29.3%) patients. There was no difference in 3-month mortality between early and late tracheostomy in either our primary analysis (hazard ratio [HR]=0.96; 95% confidence interval [CI], 0.70-1.33) or a secondary landmark analysis (HR=0.78; 95% CI, 0.57-1.06).
conclusionsThere is a wide variation across Europe in the timing of tracheostomy for critically ill patients with COVID-19. However, we found no evidence that early tracheostomy is associated with any effect on survival amongst older critically ill patients with COVID-19. CLINICAL
trial registrationClinicalTrials.gov NCT04321265.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.