ArticleEnvironmental and molecular mutagenesis2022
Transcriptome profiling of guinea pig skin exposed to a high-power terahertz source.
Article in Environmental and molecular mutagenesis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Synergistic terahertz platforms for precision oncology.Theranostics · 2026Review
- Effect of terahertz radiation on cells and cellular structures.Frontiers of optoelectronics · 2025Review
- Transcriptome profiling of guinea pig skin exposed to a high-power terahertz source.Environmental and molecular mutagenesis · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terahertz (THz) radiation has a wide range of applications including use in medicine. However, effects of high-power THz radiation have not been clearly elucidated. We used a 2.52 THz self-made optically pumped gas THz laser, the low- and high-energy group, to irradiate the backs of Hartley guinea pigs. RNA-sequencing was done to explore global transcriptional responses in the irradiated skin. Gene Ontology analysis revealed that differentially expressed genes (DEGs) between the unexposed and low-energy exposed groups were associated with skin development, skin barrier establishment, and multicellular organismal water homeostasis or water loss regulation via the skin. On the other hand, comparison between the unexposed and high-energy exposed groups showed that the DEGs mediated monocarboxylic acid metabolism, blood vessel morphogenesis, establishment of skin barrier, blood vessel development, or angiogenesis. Our analyses demonstrate the potential effects of high-power THz source on the skin and sets the basis for further studies on the safety and application of the high-power THz in dermatology.
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