Evidence map›Paper›PMID 34954808›Full record

ArticleMolecular biology reports2022

The light response in chickens divergently selected for feather pecking behavior reveals mechanistic insights towards psychiatric disorders.

Clemens Falker-Gieske, Jörn Bennewitz, Jens Tetens

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Clemens Falker-GieskeDivision of Functional Breeding, Department of Animal Sciences, Georg-August-Universität Göttingen, Burckhardtweg 2, 37077, Göttingen, Germany. clemens.falker-gieske@uni-goettingen.de.ORCID http://orcid.org/0000-0001-9160-1909
Jörn BennewitzInstitute of Animal Science, University of Hohenheim, Garbenstr. 17, 70599, Stuttgart, Germany.
Jens TetensDepartment of Animal Sciences, Georg-August-University, Burckhardtweg 2, 37077, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5352-464X
University of Göttingen · DEUniversity of Hohenheim · DE

Funding

Deutsche Forschungsgemeinschaft BE3703/8-2Deutsche Forschungsgemeinschaft TE622/4-2
6 · The paper itself

Abstract

backgroundFeather pecking is a serious behavioral disorder in chickens that has a considerable impact on animal welfare and poses an economic burden for poultry farming. To study the underlying genetics of feather pecking animals were divergently selected for feather pecking over 15 generations based on estimated breeding values for the behavior. METHODS AND

resultsBy characterizing the transcriptomes of whole brains isolated from high and low feather pecking chickens in response to light stimulation we discovered a putative dysregulation of micro RNA processing caused by a lack of Dicer1. This results in a prominent downregulation of the GABRB2 gene and other GABA receptor transcripts, which might cause a constant high level of excitation in the brains of high feather pecking chickens. Moreover, our results point towards an increase in immune system-related transcripts that may be caused by higher interferon concentrations due to Dicer1 downregulation.

conclusionBased on our results, we conclude that feather pecking in chickens and schizophrenia in humans have numerous common features. For instance, a Dicer1 dependent disruption of miRNA biogenesis and the lack of GABRB2 expression have been linked to schizophrenia pathogenesis. Furthermore, disturbed circadian rhythms and dysregulation of genes involved in the immune system are common features of both conditions.

Indexed as

AnimalsBehavior, AnimalBrainChickensDEAD-box RNA HelicasesDisease Models, AnimalFeathersGene ExpressionLightMental DisordersObsessive BehaviorRibonuclease IIITranscriptomeDEAD-box RNA HelicasesRibonuclease IIIFeather peckingGABAGenome-wide association studySchizophreniaTranscriptomics

Identifiers

PMID34954808
PMCPMC8825407
OpenAlexW4200482450

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.