Evidence map›Paper›PMID 34954700›Full record

ReviewCurrent opinion in rheumatology2022

Advances in understanding and examining lymphatic function: relevance for understanding autoimmunity.

William Ambler, Laura Santambrogio, Theresa T Lu

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

William AmblerAutoimmunity and Inflammation Program, Hospital for Special Surgery.
Laura SantambrogioEnglander Institute of Precision Medicine.
Theresa T LuAutoimmunity and Inflammation Program, Hospital for Special Surgery.
Cornell University · USHospital for Special Surgery · USWeill Cornell Medicine · US

Funding

Role of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2009 to 2024
$36.2M
Vascular-stromal function and regulation in immunityR01AI079178 · NIAID · HOSPITAL FOR SPECIAL SURGERY · PI Theresa T. Lu · 2010 to 2026
$6.6M
DYNAMICS AND TUNING OF THE MHC II PRESENTED PEPTIDOMER01AI137198 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SANTAMBROGIO, LAURA, STERN, LAWRENCE J. · 2018 to 2022
$4.6M
NIAID NIH HHS R01 AI079178NIAID NIH HHS R01 AI137198NIA NIH HHS P01 AG031782
6 · The paper itself

Abstract

purpose of reviewThe aim of this review is to give insights into how novel lymphatics functions may influence autoimmunity. RECENT

findingsThe lymphatic system connects peripheral tissues to draining lymph nodes to regulate adaptive immunity and directly interfaces with leukocytes in lymph vessels and in the lymph node. Here, we discuss recent findings showing evidence of dysfunctional lymphatics in autoimmune disease, new understanding of how afferent lymphatic regulation can modulate immunity, lymph node lymphatic heterogeneity and how these lymphatics can directly modulate lymphocyte function, how this understanding can be harnessed for new therapeutics, and new tools for the investigation of lymphatic and immune biology. SUMMARY: Lymphatics have an active role in the regulation of inflammation and the adaptive immune response. Here, we review recent findings in lymphatics biology in peripheral tissues and lymph nodes and emphasize the relevance for better understanding autoimmune diseases.

Indexed as

Autoimmune DiseasesLymphatic VesselsAutoimmunityHumansLymphatic SystemLymph Nodes

Identifiers

PMID34954700
PMCPMC11742177
OpenAlexW4200156167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.