Evidence map›Paper›PMID 34954694›Full record

ArticleAging2021

miR-545 promotes colorectal cancer by inhibiting transferring in the non-normal ferroptosis signaling.

Sixin Zheng, Lingling Hu, Qingwen Song, Yuqiang Shan, Guang Yin, Hanzhang Zhu, Wencheng Kong, Chunhua Zhou

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Epigenetic regulation of ferroptosis in gastrointestinal cancers (Review).International journal of molecular medicine · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. MIR210HG Accelerates the Progression of Colorectal Cancer and Affects the Function of Colorectal Cancer Cells by Downregulating miR-1226-3p.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. The interplay of miRNAs and ferroptosis in diseases related to iron overload.Apoptosis : an international journal on programmed cell death · 2024
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sixin ZhengDepartment of General Surgery, Affiliated Hangzhou First People Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province 310006, PR China.
Lingling HuDepartment of Medical Quality Management, Affiliated Hangzhou First People Hospital, Zhejing University School of Medicine, Hangzhou City, Zhejiang Province 310006, PR China.
Qingwen SongDepartment of Medical Quality Management, Affiliated Hangzhou First People Hospital, Zhejing University School of Medicine, Hangzhou City, Zhejiang Province 310006, PR China.
Yuqiang ShanDepartment of General Surgery, Affiliated Hangzhou First People Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province 310006, PR China.
Guang YinDepartment of General Surgery, Affiliated Hangzhou First People Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province 310006, PR China.
Hanzhang ZhuDepartment of General Surgery, Affiliated Hangzhou First People Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province 310006, PR China.
Wencheng KongDepartment of General Surgery, Affiliated Hangzhou First People Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province 310006, PR China.
Chunhua ZhouDepartment of General Surgery, Affiliated Hangzhou First People Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province 310006, PR China.
Hangzhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we examined whether and how miR-545 modulates ferroptosis in colorectal cancer (CRC). HT-29 and HCT-116 human CRC cell viability was examined using a CCK-8 assay and malondialdehyde (MDA) and Fe

Indexed as

Cell SurvivalFerroptosisSignal TransductionAnimalsColorectal NeoplasmsHCT116 CellsHumansMiceMice, NudeMicroRNAsPiperazinesReactive Oxygen SpecieserastinMicroRNAsMIR545 microRNA, humanPiperazinesReactive Oxygen Speciescolorectal cancerferroptosismiR-545transferrin

Identifiers

PMID34954694
PMCPMC8751587
OpenAlexW4200562315

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.