Evidence map›Paper›PMID 34954653›Full record

ArticleMultiple sclerosis and related disorders2022

Pandemic-associated mental health changes in youth with neuroinflammatory disorders.

Lindsey M Logan, Samantha Stephens, Beyza Ciftci-Kavaklioglu, Tara Berenbaum, Mina Ly, Giulia Longoni, E Ann Yeh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lindsey M LoganHospital for Sick Children, Division of Neurology, Department of Pediatrics, Division of Neurosciences and Mental Health, SickKids Research Institute, Canada; University of Toronto, Canada.
Samantha StephensHospital for Sick Children, Division of Neurology, Department of Pediatrics, Division of Neurosciences and Mental Health, SickKids Research Institute, Canada; University of Toronto, Canada.
Beyza Ciftci-KavakliogluHospital for Sick Children, Division of Neurology, Department of Pediatrics, Division of Neurosciences and Mental Health, SickKids Research Institute, Canada; University of Toronto, Canada; University of Manitoba, Canada.
Tara BerenbaumHospital for Sick Children, Division of Neurology, Department of Pediatrics, Division of Neurosciences and Mental Health, SickKids Research Institute, Canada.
Mina LyHospital for Sick Children, Division of Neurology, Department of Pediatrics, Division of Neurosciences and Mental Health, SickKids Research Institute, Canada.
Giulia LongoniHospital for Sick Children, Division of Neurology, Department of Pediatrics, Division of Neurosciences and Mental Health, SickKids Research Institute, Canada; University of Toronto, Canada.
E Ann YehHospital for Sick Children, Division of Neurology, Department of Pediatrics, Division of Neurosciences and Mental Health, SickKids Research Institute, Canada; University of Toronto, Canada. Electronic address: ann.yeh@sickkids.ca.
SickKids Foundation · CAUniversity of Toronto · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildren with neuroinflammatory disorders have high rates of anxiety and depression, alongside low rates of physical activity. Given general concerns for mental and physical health in children during the COVID-19 pandemic lockdown, here we sought to understand how sleep, anxiety, depression, and physical activity changed with the lockdown in children with neuroinflammatory disorders. We hypothesized that outcomes would worsen during the lockdown, and that they would differ by underlying disorder category and age.

methodsPatients attending a specialized neuroinflammatory clinic (n = 314) completed questionnaires (n = 821 responses; Jan 2017-Aug 2020) assessing sleep, anxiety, depression, and physical activity. Respondents had either: childhood-onset chronic or recurrent neuroinflammatory disorders (CRNI), a history of Autoimmune Encephalitis (AE) or Monophasic Acquired Demyelinating Syndromes (monoADS). We performed linear mixed models to examine the association between our outcome measures (sleep, anxiety, depression, and physical activity) and categories of disorder type, sex, age, physical activity, relapses, and time (pre- vs. post- COVID-19 lockdown). Participant ID acted as a random effect, to account for repeated measures.

resultsSleep significantly increased in the first 6 months of the COVID-19 lockdown (F

conclusionFor youth with neuroinflammatory disorders, the COVID-19 pandemic lockdown resulted in increased hours of nighttime sleep but did not result in significant overall changes in self-reported anxiety or depression. Pre-lockdown, teenagers had higher depression and anxiety scores than preteens. Post-lockdown, anxiety and depression scores decreased in teenagers compared to pre-teens. Physical activity was low both pre- and post-lockdown, and rates of anxiety were higher for inactive participants at both timepoints. Differences based on age suggest that younger children (<13 years) were more negatively affected by the pandemic than older children (≥ 13 years).

Indexed as

COVID-19PandemicsAdolescentAnxietyChildCommunicable Disease ControlDepressionHumansMental HealthNeuroinflammatory DiseasesSARS-CoV-2Mental healthNeuroinflammatory disordersPandemicPediatricPhysical activitySleep

Identifiers

PMID34954653
PMCPMC9765271
OpenAlexW4200360730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.