Evidence map›Paper›PMID 34954086›Full record

ArticleMetabolic engineering2022

Isotopically nonstationary

Cara L Sake, Alexander J Metcalf, Michelle Meagher, Jorge Di Paola, Keith B Neeves, Nanette R Boyle

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Metabolic engineering communications · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Cara L SakeDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, 80401, USA.
Alexander J MetcalfDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, 80401, USA.
Michelle MeagherDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, 80401, USA.
Jorge Di PaolaDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Keith B NeevesDepartment of Bioengineering, University of Colorado, Aurora, CO, 80045, USA; Hemophilia and Thrombosis Center, University of Colorado, Aurora, CO, 80045, USA; Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplant, University of Colorado, Aurora, CO, 80045, USA.
Nanette R BoyleDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, 80401, USA. Electronic address: nboyle@mines.edu.
Colorado School of Mines · USUniversity of Colorado Anschutz Medical Campus · USWashington University in St. Louis · US

Funding

A SYSTEMS BIOLOGY APPROACH TO IDENTIFYING THE MECHANISMS OF SEX HORMONE INDUCED THROMBOEMBOLISM IN PRE-MENOPAUSAL WOMENR33HL141794 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DI PAOLA, JORGE A, NEEVES, KEITH B · 2020 to 2022
$1.9M
A SYSTEMS BIOLOGY APPROACH TO IDENTIFYING THE MECHANISMS OF SEX HORMONE INDUCED THROMBOEMBOLISM IN PRE-MENOPAUSAL WOMENR61HL141794 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DI PAOLA, JORGE A, NEEVES, KEITH B · 2018 to 2019
$1.4M
NHLBI NIH HHS R33 HL141794NHLBI NIH HHS R61 HL141794
6 · The paper itself

Abstract

Platelet metabolism is linked to platelet hyper- and hypoactivity in numerous human diseases. Developing a detailed understanding of the link between metabolic shifts and platelet activation state is integral to improving human health. Here, we show the first application of isotopically nonstationary

Indexed as

Blood PlateletsMetabolic Flux AnalysisCarbonGlycolysisHumansPentose Phosphate PathwayCarbonBlood plateletsMetabolic flux analysisMetabolomicsThrombin

Identifiers

PMID34954086
PMCPMC8905147
OpenAlexW4220992208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.