Evidence map›Paper›PMID 34954003›Full record

ArticleInternational journal of pharmaceutics2022

Lung cell membrane-coated nanoparticles capable of enhanced internalization and translocation in pulmonary epithelial cells.

Md Golam Jakaria, Parand Sorkhdini, Dongqin Yang, Yang Zhou, Samantha A Meenach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. HumanTissue barriers · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Md Golam JakariaDepartment of Chemical Engineering, 2 East Alumni Drive, University of Rhode Island, Kingston, Rhode Island 02881, USA. Electronic address: mdgolam_jakaria@uri.edu.
Parand SorkhdiniDepartment of Molecular Microbiology and Immunology, Sidney Frank Hall, Room 258, Box G-B5, 185 Meeting Street, Brown University, Providence, Rhode Island 02912, USA. Electronic address: parand_sorkhdini@brown.edu.
Dongqin YangDepartment of Molecular Microbiology and Immunology, Sidney Frank Hall, Room 258, Box G-B5, 185 Meeting Street, Brown University, Providence, Rhode Island 02912, USA. Electronic address: dongqin_yang@brown.edu.
Yang ZhouDepartment of Molecular Microbiology and Immunology, Sidney Frank Hall, Room 258, Box G-B5, 185 Meeting Street, Brown University, Providence, Rhode Island 02912, USA. Electronic address: yang_zhou@brown.edu.
Samantha A MeenachDepartment of Chemical Engineering, 2 East Alumni Drive, University of Rhode Island, Kingston, Rhode Island 02881, USA; Department of Biomedical and Pharmaceutical Sciences, 6 Greenhouse Road, University of Rhode Island, Kingston, Rhode Island 02881, USA. Electronic address: smeenach@uri.edu.

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Bongsup P Cho · 2012 to 2026
$63.6M
Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV, HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Targeting CHI3L and its receptors in Hermansky-Pudlak Syndrome-associated lung diseaseR01HL146498 · NHLBI · BROWN UNIVERSITY · PI ZHOU, YANG · 2020 to 2024
$2.2M
Short-Term Training Program to Increase Diversity in Health-Related ResearchR25HL088992 · NHLBI · BROWN UNIVERSITY · PI ABID, RUHUL, DIAZ, JOSEPH A · 2007 to 2024
$1.9M
Role of Endothelial Anoctamin-1 in Pulmonary Arterial HypertensionR01HL148727 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL146498NHLBI NIH HHS R01 HL148727NHLBI NIH HHS R25 HL088992NIGMS NIH HHS P20 GM103430NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

Cell membrane-coated nanoparticles (CMCNP), which involve coating a core nanoparticle (NP) with cell membranes, have been gaining attention due to their ability to mimic the properties of the cells, allowing for enhanced delivery and efficacy of therapeutics. Two CMCNP systems comprised of an acetalated dextran-based NP core loaded with curcumin (CUR) coated with cell membranes derived from pulmonary epithelial cells were developed. The NP were approximately 200 nm and their surface charges varied based on their coating, where CMCNP systems exhibited negative surface charge like natural cell membranes. The NP were smooth, spherical, and homogeneous with distinct coatings on their cores. Minimal in vitro toxicity was observed for the NP and controlled release of CUR was observed. The CMCNP internalized into and translocated across an in vitro pulmonary epithelial monolayer significantly more than the control NP. Blocking endocytosis pathways reduced the transcytosis of NP, indicating a relationship between endocytosis and transcytosis. These newly developed CMCNP have the potential to be used in pulmonary drug delivery applications to potentially enhance NP internalization and transport into and across the pulmonary epithelium.

Indexed as

CurcuminNanoparticlesCell MembraneEpithelial CellsLungCurcuminAir-blood barrierCell membrane-coated nanoparticleLung cellsNanoparticle transcytosisPulmonary epithelium

Identifiers

PMID34954003
PMCPMC8792290

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.