Evidence map›Paper›PMID 34953791›Full record

ArticleThe Journal of allergy and clinical immunology2022

T

Yan Xie, Peter W Abel, Thomas B Casale, Yaping Tu

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
  2. Article
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  5. Gngt2 promotes inflammatory dendritic cell programming through an ATG5-NF-κB signaling axis in neutrophilic asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Asthma endotypes and theratypes.Chinese medical journal pulmonary and critical care medicine · 2026
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yan XieDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Neb.
Peter W AbelDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Neb.
Thomas B CasaleDepartment of Internal Medicine, University of South Florida School of Medicine, Tampa, Fla. Electronic address: tbcasale@usf.edu.
Yaping TuDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, Neb. Electronic address: Yat60399@creighton.edu.
Creighton University · USUniversity of South Florida · US

Funding

Dysregulation of RGS2 Protein and Airway Hyperresponsiveness in AsthmaR01HL116849 · NHLBI · CREIGHTON UNIVERSITY · PI TU, YAPING · 2013 to 2016
$1.4M
Neuronal P-Rex1 repression: a key factor in early-life environmental cigarette smoke exposure mediated risk of asthmaR21ES029566 · NIEHS · CREIGHTON UNIVERSITY · PI TU, YAPING · 2019 to 2020
$400k
NHLBI NIH HHS R01 HL116849NIEHS NIH HHS R21 ES029566
6 · The paper itself

Abstract

Asthma is classically described as having either a type 2 (T2) eosinophilic phenotype or a non-T2 neutrophilic phenotype. T2 asthma usually responds to classical bronchodilation therapy and corticosteroid treatment. Non-T2 neutrophilic asthma is often more severe. Patients with non-T2 asthma or late-onset T2 asthma show poor response to the currently available anti-inflammatory therapies. These therapeutic failures result in increased morbidity and cost associated with asthma and pose a major health care problem. Recent evidence suggests that some non-T2 asthma is associated with elevated T

Indexed as

Adrenal Cortex HormonesAsthmaCell DifferentiationHumansInterleukin-17Interleukin-6 InhibitorsNeutrophilsrho-Associated KinasesSeverity of Illness IndexTh17 CellsAdrenal Cortex HormonesIL17A protein, humanInterleukin-17Interleukin-6 Inhibitorsrho-Associated Kinasesairway neutrophiliacorticosteroid insensitivityIL-17IL-6non–type 2 asthmaRhoARho-associated kinasesevere asthmaT(H)17 cellstype 2 asthma

Identifiers

PMID34953791
PMCPMC8821175
OpenAlexW4200040541

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.