Evidence map›Paper›PMID 34953724›Full record

ArticleTrends in parasitology2022

The curious case of a cryptic Cryptosporidium and a missing dendritic cell subset.

Donguk Lee, Eric S Huseby, Uthaman Gowthaman

Open access · greenAbstract readComment
In one paragraph

Article in Trends in parasitology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Donguk LeeDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Eric S HusebyDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: Eric.Huseby@umassmed.edu.
Uthaman GowthamanDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: Gowthaman.Uthaman@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

TCR signaling control of thymic Treg selection and immune homeostasisR01AI143976 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BERG, LESLIE JOAN, HUSEBY, ERIC S · 2020 to 2024
$2.9M
Interplay of Regulatory Innate T Cells and Pathogenic T Clonotypes In DermatitisR01AR071269 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUSEBY, ERIC S, KANG, JOONSOO · 2017 to 2021
$2.9M
NIAID NIH HHS R01 AI143976NIAMS NIH HHS R01 AR071269
6 · The paper itself

Abstract

Animal models for studying immune responses to Cryptosporidium, a parasite that causes gastrointestinal disease, have been a challenge due to the parasite's poor infectivity in mice. Russler-Germain et al. discovered a 'commensal' strain of Cryptosporidium, capable of stable infection and vertical transmission, that elicits a T helper type 1 (Th1) response to promote intestinal homeostasis.

Indexed as

CryptosporidiosisCryptosporidiumAnimalsDendritic CellsHomeostasisIntestinesMiceCD4 T cellscommensaldendritic cellsgut immunityprotozoan

Identifiers

PMID34953724
PMCPMC9576149
OpenAlexW4200279116

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.