Evidence map›Paper›PMID 34953615›Full record

ArticleTrends in neurosciences2022

The tactile sensors of the gut.

Sarah A Najjar, Kara Gross Margolis

Open access · greenAbstract read
In one paragraph

Article in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Piezo channels in the intestinal tract.Frontiers in physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sarah A NajjarDepartment of Pediatrics, Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, USA.
Kara Gross MargolisDepartment of Pediatrics, Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, USA. Electronic address: kjg2133@cumc.columbia.edu.
Morgan Stanley Children's Hospital · US

Funding

MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENTR01NS015547 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GERSHON, MICHAEL D, MARGOLIS, KARA GROSS · 1985 to 2022
$7.2M
A Prospective Study Examining the Role of Gestational SSRI Exposure in the Development of Functional Gastrointestinal DisordersR01DK130517 · NIDDK · NEW YORK UNIVERSITY · PI MARGOLIS, KARA GROSS, SAVIDGE, TOR C. · 2021 to 2024
$2.5M
Linkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brainR01DK126644 · NIDDK · NEW YORK UNIVERSITY · PI MARGOLIS, KARA GROSS · 2021 to 2024
$1.9M
The role of mucosal serotonin in visceral nociception and gut motilityF32DK132810 · NIDDK · NEW YORK UNIVERSITY · PI NAJJAR, SARAH · 2022 to 2024
$218k
NIDDK NIH HHS F32 DK132810NIDDK NIH HHS R01 DK126644NIDDK NIH HHS R01 DK130517NINDS NIH HHS R01 NS015547
6 · The paper itself

Abstract

In a recent study, Treichel, Finholm et al. showed that the mechanoreceptor Piezo2 enables enteroendocrine cells in the intestinal epithelium to sense luminal contents. Through neuroepithelial signaling, these cells modulate intestinal motility and transit of digestive products.

Indexed as

Ion ChannelsTouchEnteroendocrine CellsHumansMechanoreceptorsIon Channelsenteroendocrine cellsGI physiologyion channelsmechanosensitivityneuroepithelial connectionPiezo2

Identifiers

PMID34953615
PMCPMC12914874
OpenAlexW4200497477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.