Evidence map›Paper›PMID 34953280›Full record

ArticleMolecular immunology2022

Healthy myeloid-derived suppressor cells express the surface ectoenzyme Vanin-2 (VNN2).

David C Soler, Amber Kerstetter-Fogle, Andrew B Young, Pat Rayman, James H Finke, Sarah M Debanne, Kevin D Cooper, Jill Barnholtz-Sloan, Andrew E Sloan, Thomas S McCormick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

David C SolerThe Department of Neurosurgery, USA; The Brain Tumor and Neuro-Oncology Center, and the Center of Excellence for Translational Neuro-Oncology, USA; University Hospitals-Seidman Center and the Case Comprehensive Cancer Center, USA.
Amber Kerstetter-FogleThe Department of Neurosurgery, USA; The Brain Tumor and Neuro-Oncology Center, and the Center of Excellence for Translational Neuro-Oncology, USA; University Hospitals-Seidman Center and the Case Comprehensive Cancer Center, USA.
Andrew B YoungThe Department of Dermatology, University Hospitals-Cleveland Medical Center and the Case Western University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA; The Murdough Family Center for Psoriasis, University Hospitals-Cleveland Medical Center and the Case Western University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
Pat RaymanCase Western Reserve University School of Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
James H FinkeCase Western Reserve University School of Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Sarah M DebanneEpidemiology and Biostatistics, USA.
Kevin D CooperThe Department of Dermatology, University Hospitals-Cleveland Medical Center and the Case Western University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA; The Murdough Family Center for Psoriasis, University Hospitals-Cleveland Medical Center and the Case Western University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
Jill Barnholtz-SloanThe Department of Neurosurgery, USA; The Brain Tumor and Neuro-Oncology Center, and the Center of Excellence for Translational Neuro-Oncology, USA; University Hospitals-Seidman Center and the Case Comprehensive Cancer Center, USA; Epidemiology and Biostatistics, USA.
Andrew E SloanThe Department of Neurosurgery, USA; The Brain Tumor and Neuro-Oncology Center, and the Center of Excellence for Translational Neuro-Oncology, USA; University Hospitals-Seidman Center and the Case Comprehensive Cancer Center, USA.
Thomas S McCormickThe Department of Dermatology, University Hospitals-Cleveland Medical Center and the Case Western University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA; The Murdough Family Center for Psoriasis, University Hospitals-Cleveland Medical Center and the Case Western University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA. Electronic address: tsm4@case.edu.
Center for Neuro-Oncology · USUniversity Hospitals of Cleveland · USCancer Research And Biostatistics · USCleveland Clinic Lerner College of Medicine · US

Funding

Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1988 to 2015
$9.1M
Systems Biology CoreP50AR055508 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI DIAZ-INSUA, MIREYA · 2007 to 2011
$6.8M
Psoriatic Regulatory T cell DysfunctionR01AR051498 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 2004 to 2014
$3.5M
Differential Diagnosis of recurrent GBM versus Radiation Necrosis using MDSCbiomarkersR21CA256573 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MCCORMICK, THOMAS S, SLOAN, ANDREW E · 2021 to 2022
$409k
NCI NIH HHS R21 CA256573NIAMS NIH HHS P30 AR039750NIAMS NIH HHS P50 AR055508NIAMS NIH HHS R01 AR051498
6 · The paper itself

Abstract

Study of human monocytic Myeloid-Derived Suppressor cells Mo-MDSC (CD14

Indexed as

AmidohydrolasesBiomarkersCD8-Positive T-LymphocytesCell Adhesion MoleculesCell ProliferationGliomaGPI-Linked ProteinsHLA-DR AntigensHumansLipopolysaccharide ReceptorsLymphocyte ActivationMembrane ProteinsMonocytesMyeloid-Derived Suppressor CellsNeoplasm GradingProtein Array AnalysisAmidohydrolasesBiomarkersCD14 protein, humanCD33 protein, humanCell Adhesion MoleculesGPI-Linked ProteinsHLA-DR AntigensLipopolysaccharide ReceptorsMembrane ProteinsSialic Acid Binding Ig-like Lectin 3VNN2 protein, humanGPI-80ImmunosuppressionMo-MDSCVNN2

Identifiers

PMID34953280
PMCPMC8800381
OpenAlexW4200304438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.