ArticleESC heart failure2022
Novel active fixation lead guided by electrical delay can improve response to cardiac resynchronization therapy in heart failure.
Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- New Diseases Related to Cardiac Implantable Electronic Devices (CIEDs): An Overview.Journal of clinical medicine · 2025Review
- The Long-Term Benefit of Sacubitril/Valsartan in Patients with HFrEF: A 5-Year Follow-Up Study in a Real World Population.Journal of clinical medicine · 2023Article
- Novel active fixation lead guided by electrical delay can improve response to cardiac resynchronization therapy in heart failure.ESC heart failure · 2022Article
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Authors and funding
6 authors.
Funding
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Abstract
aimsCardiac resynchronization therapy (CRT) for heart failure (HF) recently has shown optimal results by targeting electrically delayed sites in coronary sinus (CS) branches. However this purpose often cannot be reached because of unstable left ventricular (LV) lead position. In current study were assessed the long-term effects of the novel active fixation LV lead in CS, guided by electrical delay (QLV), in patients with HF due to coronary artery disease.
methodsOne hundred eighty-five consecutive patients underwent CRT with intraoperative evaluation of QLV in the target position of the LV lead. When the novel active fixation LV lead was available, 98 consecutive patients received it, composing the Fix group. They were compared with 87 patients with a conventional passive fixation lead (No Fix group). The final LV lead position was assessed by fluoroscopy. Clinical response to CRT was assessed within a period of about 3 years: patients experiencing HF rehospitalization and death due to HF were defined as non-responders.
resultsThere were no significant differences between groups in the final position of LV lead in left anterior oblique view (Pearson χ
conclusionsThe novel active fixation LV lead allowed to target sites with greater QLV. Often maximum QLV was documented in basal segments, were stability of conventional passive fixation leads is not enough. Patients receiving it experienced less HF rehospitalizations and less death due to HF. Active fixation lead in CS guided by QLV can improve long-term prognosis in patients with HF due to coronary artery disease undergoing to CRT.
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