ArticleCNS neuroscience & therapeutics2022
Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response.
Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Uncovering oscillatory dysregulation associated with suicide risk in major depressive disorder: a narrative review.Translational psychiatry · 2026Review
- Spatiotemporal dynamics of amygdala during implicit and explicit facial emotional recognition in major depressive disorder: An MEG study.Psychological medicine · 2025Article
- γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.Military Medical Research · 2025Review
- Delta-alpha/beta coupling as a signature of visual working memory in the prefrontal cortex.iScience · 2024Article
- Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response.CNS neuroscience & therapeutics · 2022Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe diversity of treatment outcomes for major depressive disorder (MDD) remains uncertain in neuropathology. The current study aimed at exploring electrophysiological biomarkers associated with treatment response.
methodsThe present study recruited 130 subjects including 100 MDD patients and 30 healthy controls. All subjects participated in a sad expression recognition task while their magnetoencephalography data were recorded. Patients who had a reduction of at least 50% in disorder severity at endpoint (>2 weeks) were considered as responders. Within-frequency power and phase-amplitude coupling were measured for the brain regions involved in the emotional visual information processing pathways.
resultsThe significant alpha-gamma decoupling from the right thalamus to the right amygdala in unconscious processing and from right orbital frontal cortices to the right amygdala in conscious processing was found in non-responders relative to responders and healthy controls. These kinds of dysregulation could also predict the potential treatment response.
conclusionThe attenuated alpha-gamma coupling in dual pathways indicated increased sensitivity to the negative emotional information and reduced moderated effect of the amygdala, which might cause insensitivity to antidepressant treatment and could be regarded as potential neural mechanisms for treatment response prediction.
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