ArticleJournal of clinical laboratory analysis2022
Hsa_circ_0000437 upregulates and promotes disease progression in rheumatic valvular heart disease.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.Journal of the American Heart Association · 2026Article
- Article
- [Circ_0000437 promotes proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cells by targeting the let-7b-5p/CTPS1 axis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Potential Diagnostic Value of Circular RNA hsa_circ_0008882 in Rheumatic Valvular Heart Disease.International journal of general medicine · 2025Article
- Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker.Frontiers in cardiovascular medicine · 2025Article
- Review
- The Landscape of Circular RNAs in Cardiovascular Diseases.International journal of molecular sciences · 2023Review
- Hsa_circ_0003748 promotes disease progression in rheumatic valvular heart disease by sponging miR-577.Journal of clinical laboratory analysis · 2022Article
- Upregulation of hsa_circ_0000977 participates in esophageal squamous cancer progression by sponging miR-874-3p.Journal of clinical laboratory analysis · 2022Article
- Hsa_circ_0000437 upregulates and promotes disease progression in rheumatic valvular heart disease.Journal of clinical laboratory analysis · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCurrently, the diagnosis and outcome of rheumatic valvular heart disease (RVHD) are less than ideal, and there are no accurate biomarkers. Circular RNA (circRNA) might participate in the occurrence and development of RVHD. MATERIALS AND
methodsWe use circRNA microarray to filter out the target has_circ_0000437. qRT-PCR was used to measure the expression levels of hsa_circ_0000437 in RVHD plasma samples. We assessed the diagnostic value of hsa_circ_0000437 in RVHD. Cell function in vitro experiment was to explore the effect of has_circ_0000437 on RVHD.
resultsHas_circ_0000437 is highly expressed in RVHD (p < 0.001). has_circ_0000437 has the diagnostic value in RVHD. In RVHD, hsa_circ_0000437 can promote cell proliferation and migration but inhibits its apoptosis. This may be due to the combination of has_circ_0000437 and target miRNA in the cytoplasm that affects the progress of RVHD.
conclusionsHas_circ_0000437 can promote the process of RVHD and may be a potential for the diagnosis and treatment of RVHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.