Evidence map›Paper›PMID 34952908›Full record

ArticleScientific reports2021

Development of a prediction score for in-hospital mortality in COVID-19 patients with acute kidney injury: a machine learning approach.

Daniela Ponce, Luís Gustavo Modelli de Andrade, Rolando Claure-Del Granado, Alejandro Ferreiro-Fuentes, Raul Lombardi

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Calibration and prediction of results after failed injection in SPECT renal dynamic imaging.American journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Observational
  10. Artificial Intelligence in Acute Kidney Injury Prediction.Advances in chronic kidney disease · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Viral Glomerulopathy.Glomerular diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniela Ponce *Department of Internal Medicine, Botucatu Medical School, University of São Paulo State-UNESP, Avenida Professor Mario Rubens Montenegro, Botucatu, São Paulo, 18618-687, Brazil. daniela.ponce@unesp.br.ORCID http://orcid.org/0000-0002-6178-6938
Luís Gustavo Modelli de Andrade *Department of Internal Medicine, Botucatu Medical School, University of São Paulo State-UNESP, Avenida Professor Mario Rubens Montenegro, Botucatu, São Paulo, 18618-687, Brazil.ORCID http://orcid.org/0000-0002-0230-0766
Rolando Claure-Del Granado *Division of Nephrology, Hospital Obrero No. 2 - CNS, Universidad Mayor de San Simon, School of Medicine, Cochabamba, Bolivia.ORCID http://orcid.org/0000-0002-8163-3779
Alejandro Ferreiro-Fuentes *Division of Nephrology, School of Medicine, Universidad de La República, Montevideo, Uruguay.
Raul Lombardi *Division of Nephrology, School of Medicine, Universidad de La República, Montevideo, Uruguay.ORCID http://orcid.org/0000-0002-2398-794X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is frequently associated with COVID-19 and it is considered an indicator of disease severity. This study aimed to develop a prognostic score for predicting in-hospital mortality in COVID-19 patients with AKI (AKI-COV score). This was a cross-sectional multicentre prospective cohort study in the Latin America AKI COVID-19 Registry. A total of 870 COVID-19 patients with AKI defined according to the KDIGO were included between 1 May 2020 and 31 December 2020. We evaluated four categories of predictor variables that were available at the time of the diagnosis of AKI: (1) demographic data; (2) comorbidities and conditions at admission; (3) laboratory exams within 24 h; and (4) characteristics and causes of AKI. We used a machine learning approach to fit models in the training set using tenfold cross-validation and validated the accuracy using the area under the receiver operating characteristic curve (AUC-ROC). The coefficients of the best model (Elastic Net) were used to build the predictive AKI-COV score. The AKI-COV score had an AUC-ROC of 0.823 (95% CI 0.761-0.885) in the validation cohort. The use of the AKI-COV score may assist healthcare workers in identifying hospitalized COVID-19 patients with AKI that may require more intensive monitoring and can be used for resource allocation.

Indexed as

Hospital MortalityMachine LearningAcute Kidney InjuryAgedArea Under CurveComorbidityCOVID-19FemaleHumansMaleMiddle AgedProspective StudiesRegistriesRisk FactorsROC CurveSARS-CoV-2

Identifiers

PMID34952908
PMCPMC8709848

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.